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Descriptor English: Apolipoproteins E
Descriptor Spanish: Apolipoproteínas E
Descriptor apolipoproteínas E
Entry term(s) Apo-E
Scope note: Clase de componentes proteicos que se han encontrado en varias lipoproteínas que incluyen las LIPOPROTEÍNAS DE ALTA DENSIDAD, LIPOPROTEÍNAS DE MUY BAJA DENSIDAD y QUILOMICRONES. Sintetizada en la mayoría de los órganos, la Apo E es importante en el transporte global de los lípidos y del colesterol por todo el cuerpo. La Apo E es también un ligando para los receptores de LDL (RECEPTORES LDL) que median en la unión, internalización y catabolismo de las partículas de lipoproteínas en las células. Hay varias isoformas alélicas (tales como E2, E3 y E4). La deficiencia o los defectos en la Apo E son causas de HIPERLIPOPROTEINEMIA TIPO III.
Descriptor Portuguese: Apolipoproteínas E
Descriptor French: Apolipoprotéines E
Entry term(s): Apo E
Apo E Isoproteins
Apo-E
ApoE
Apolipoprotein E Isoproteins
Apoprotein (E)
Apoproteins E
Isoproteins, Apo E
Isoproteins, Apolipoprotein E
Tree number(s): D10.532.091.500
D12.776.070.400.500
D12.776.521.120.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001057
Scope note: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Apolipoproteins (1977-1984)
Public MeSH Note: 1985; APOLIPOPROTEIN E ISOPROTEINS was indexed under APOLIPOPROTEINS E 1985-2006 & under APOLIPOPROTEINS 1983-1984
History Note: 1985; for APOLIPOPROTEIN E ISOPROTEINS use APOLIPOPROTEINS E 1985-2006 & use APOLIPOPROTEINS 1983-1984
DeCS ID: 1063
Unique ID: D001057
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1985/01/01
Date of Entry: 1984/05/25
Revision Date: 2006/07/05
Apolipoproteins E - Preferred
Concept UI M0001601
Scope note A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
Preferred term Apolipoproteins E
Entry term(s) Apo E
Apo-E
ApoE
Apolipoprotein E Isoproteins - Narrower
Concept UI M0114996
Preferred term Apolipoprotein E Isoproteins
Entry term(s) Apo E Isoproteins
Isoproteins, Apo E
Isoproteins, Apolipoprotein E
Apoproteins E - Broader
Concept UI M0001602
Preferred term Apoproteins E
Entry term(s) Apoprotein (E)



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