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Descriptor English: Argininosuccinate Synthase
Descriptor Spanish: Argininosuccinato Sintasa
Descriptor argininosuccinato sintasa
Scope note: nzima del ciclo de la urea que cataliza la formación de ácido argininosuccínico a partir de citrulina y ácido aspártido, en presencia de ATP. La ausencia o deficiencia de esta enzima causa en lel hombre la enfermedad metabólica conocida como CITRULINEMIA. EC 6.3.4.5.
Descriptor Portuguese: Argininossuccinato Sintase
Descriptor French: Argininosuccinate synthase
Entry term(s): Argininosuccinate Synthetase
Synthase, Argininosuccinate
Synthetase, Argininosuccinate
Tree number(s): D08.811.464.259.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001124
Scope note: An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Annotation: /defic: consider also CITRULLINEMIA
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.3.4.5
CAS Type 1 Name: L-Citrulline:L-aspartate ligase (AMP-forming)
Previous Indexing: Arginine (1973-1974)
Ligases (1973-1974)
Succinates (1973-1974)
Public MeSH Note: 98; see ARGININOSUCCINATE SYNTHETASE 1991-97; see LIGASES 1975-90
History Note: 98(75)
Related: Citrullinemia MeSH
DeCS ID: 1127
Unique ID: D001124
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
Argininosuccinate Synthase - Preferred
Concept UI M0001688
Scope note An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Preferred term Argininosuccinate Synthase
Entry term(s) Argininosuccinate Synthetase
Synthase, Argininosuccinate
Synthetase, Argininosuccinate



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