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Descriptor English: Adenylosuccinate Synthase
Descriptor Spanish: Adenilosuccinato Sintasa
Descriptor adenilosuccinato sintasa
Scope note: Ligasa carbono-nitrógeno. Durante la biosíntesis de ribonucleótidos de purina, esta enzima cataliza la síntesis de adenilsuccinato a partir de GTP, IMP y aspartato, con formación de ortofosfato y GDP. EC 6.3.4.4.
Descriptor Portuguese: Adenilossuccinato Sintase
Descriptor French: Adenylosuccinate synthase
Entry term(s): Adenylosuccinate Synthetase
Succino AMP Synthetase
Succino-AMP Synthetase
Synthase, Adenylosuccinate
Synthetase, Adenylosuccinate
Synthetase, Succino-AMP
Tree number(s): D08.811.464.259.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000265
Scope note: A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.3.4.4
CAS Type 1 Name: IMP:L-aspartate ligase (GDP-forming)
Previous Indexing: Aspartic Acid (1966-1978)
Inosine Monophosphate (1975-1978)
Inosine Nucleotides (1971-1978)
Ligases (1966-1978)
Public MeSH Note: 98; see ADENYLOSUCCINATE SYNTHETASE 1991-97; see LIGASES 1979-90
History Note: 98(79)
DeCS ID: 272
Unique ID: D000265
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1978/05/16
Revision Date: 2003/07/09
Adenylosuccinate Synthase - Preferred
Concept UI M0000415
Scope note A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
Preferred term Adenylosuccinate Synthase
Entry term(s) Adenylosuccinate Synthetase
Succino AMP Synthetase
Succino-AMP Synthetase
Synthase, Adenylosuccinate
Synthetase, Adenylosuccinate
Synthetase, Succino-AMP



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