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Descriptor English: Formate-Tetrahydrofolate Ligase
Descriptor Spanish: Formiato-Tetrahidrofolato Ligasa
Descriptor formato-tetrahidrofolato ligasa
Entry term(s) tetrahidrofolato formilasa
Scope note: Liagasa de carbón-nitrógeno que cataliza la formación de 10-formiltetrahidrofolato a partir de formiato y TETRAHIDROFOLATOS, en presencia de ATP. En eucariotas superiores la enzima también tiene actividad METILENOTETRAHIDROFOLATO DESHIDROGENASA (NADP+) y METENILTETRAHIDROFOLATO CICLOHIDROLASA.
Descriptor Portuguese: Formiato-Tetra-Hidrofolato Ligase
Descriptor French: Formate-tetrahydrofolate ligase
Entry term(s): Formate Tetrahydrofolate Ligase
Formylase, Tetrahydrofolate
Formyltetrahydrofolate Synthetase
Ligase, Formate-Tetrahydrofolate
Synthetase, Formyltetrahydrofolate
Tetrahydrofolate Formylase
Tree number(s): D08.811.464.259.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005574
Scope note: A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.3.4.3
CAS Type 1 Name: Formate:tetrahydrofolate ligase (ADP-forming)
Previous Indexing: Formic Acids (1969-1974)
Ligases (1969-1974)
Tetrahydrofolates (1972-1974)
Public MeSH Note: 98; see FORMYLTETRAHYDROFOLATE SYNTHETASE 1991-97; see LIGASES 1975-90
History Note: 98(75)
Related: Methenyltetrahydrofolate Cyclohydrolase MeSH
Methylenetetrahydrofolate Dehydrogenase (NADP) MeSH
DeCS ID: 5709
Unique ID: D005574
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/10
Formate-Tetrahydrofolate Ligase - Preferred
Concept UI M0008774
Scope note A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Preferred term Formate-Tetrahydrofolate Ligase
Entry term(s) Formate Tetrahydrofolate Ligase
Formylase, Tetrahydrofolate
Formyltetrahydrofolate Synthetase
Ligase, Formate-Tetrahydrofolate
Synthetase, Formyltetrahydrofolate
Tetrahydrofolate Formylase



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