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Descriptor English: Quinidine
Descriptor Spanish: Quinidina
Descriptor quinidina
Scope note: Isómero óptico de la quinina, extraído de la corteza del árbol CHINCHONA y especies similares de plantas. Este alcaloide deprime la excitabilidad de los músculos cardíaco y esquelético al bloquear el trasporte de sodio y potasio a través de la membrana celular. Prolonga los POTENCIALES DE ACCIÓN celular y disminuye el automatismo. La quinidina bloquea también la neurotransmisión muscarínica y alfa-adrenérgica.
Descriptor Portuguese: Quinidina
Descriptor French: Quinidine
Entry term(s): Adaquin
Apo Quinidine
Apo-Quinidine
Chinidin
Quincardine
Quinidex
Quinidine Sulfate
Quinora
Sulfate, Quinidine
Tree number(s): D03.132.206.636
D03.605.687.637
D03.633.100.810.699
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011802
Scope note: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adrenergic alpha-Antagonists
Anti-Arrhythmia Agents
Antimalarials
Enzyme Inhibitors
Muscarinic Antagonists
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP2D6 Inhibitors
Registry Number: ITX08688JL
CAS Type 1 Name: Cinchonan-9-ol, 6'-methoxy-, (9S)-
DeCS ID: 12239
Unique ID: D011802
NLM Classification: QV 155
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Quinidine - Preferred
Concept UI M0018341
Scope note An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Preferred term Quinidine
Entry term(s) Chinidin
Apo-Quinidine - Narrower
Concept UI M0474991
Preferred term Apo-Quinidine
Entry term(s) Apo Quinidine
Quinora - Narrower
Concept UI M0018343
Preferred term Quinora
Quinidex - Narrower
Concept UI M0474993
Preferred term Quinidex
Quinidine Sulfate - Narrower
Concept UI M0018342
Preferred term Quinidine Sulfate
Entry term(s) Sulfate, Quinidine
Adaquin - Narrower
Concept UI M0474990
Preferred term Adaquin
Quincardine - Narrower
Concept UI M0474992
Preferred term Quincardine



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