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Descriptor English: Palonosetron
Descriptor Spanish: Palonosetrón
Descriptor Portuguese: Palonossetrom
Descriptor French: Palonosétron
Entry term(s): 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
2-QHBIQO
Aloxi
Palonosetron Hydrochloride
Palonosetron, (3R)-
Palonosetron, (R-(R*,R*))-isomer
Palonosetron, (R-(R*,S*))-isomer
Palonosetron, (S-(R*,S*))-isomer
RS 25233 197
RS 25233 198
RS 25233-197
RS 25233-198
RS 25233197
RS 25233198
RS 25259
RS 25259 197
RS 25259 198
RS 25259-197
RS 25259-198
RS 25259197
RS 25259198
RS-25233-197
RS-25233-198
RS-25259
RS-25259-197
RS-25259-198
RS25233197
RS25233198
RS25259
RS25259197
RS25259198
Tree number(s): D03.605.687.319
D03.633.100.531.629
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077924
Scope note: Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiemetics
Serotonin 5-HT3 Receptor Antagonists
Registry Number: 5D06587D6R
CAS Type 1 Name: 1H-Benz(de)isoquinolin-1-one, 2-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-, (3aS)-
Public MeSH Note: 2019; PALONOSETRON was indexed under ISOQUINOLINES and QUINUCLIDINES 1993-2018
History Note: 2019 (1993)
DeCS ID: 57774
Unique ID: D000077924
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/05/21
Palonosetron - Preferred
Concept UI M0221985
Scope note Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting.
Preferred term Palonosetron
Entry term(s) 2-QHBIQO
Palonosetron, (R-(R*,R*))-isomer - Narrower
Concept UI M0326296
Preferred term Palonosetron, (R-(R*,R*))-isomer
Entry term(s) Palonosetron, (3R)-
Palonosetron, (R-(R*,S*))-isomer - Narrower
Concept UI M0326297
Preferred term Palonosetron, (R-(R*,S*))-isomer
RS 25259-198 - Narrower
Concept UI M0221980
Preferred term RS 25259-198
Entry term(s) RS 25259 198
RS 25259198
RS-25259-198
RS25259198
2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one - Broader
Concept UI M000642093
Preferred term 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
RS 25233-198 - Narrower
Concept UI M0221978
Preferred term RS 25233-198
Entry term(s) RS 25233 198
RS 25233198
RS-25233-198
RS25233198
RS 25259 - Narrower
Concept UI M0391264
Preferred term RS 25259
Entry term(s) RS-25259
RS25259
RS 25259-197 - Narrower
Concept UI M0221979
Preferred term RS 25259-197
Entry term(s) RS 25259 197
RS 25259197
RS-25259-197
RS25259197
Aloxi - Narrower
Concept UI M0452616
Preferred term Aloxi
Palonosetron, (S-(R*,S*))-isomer - Narrower
Concept UI M0326295
Preferred term Palonosetron, (S-(R*,S*))-isomer
Palonosetron Hydrochloride - Narrower
Concept UI M0452615
Preferred term Palonosetron Hydrochloride
RS 25233-197 - Narrower
Concept UI M0221977
Preferred term RS 25233-197
Entry term(s) RS 25233 197
RS 25233197
RS-25233-197
RS25233197



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