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Descriptor English: Saquinavir
Descriptor Spanish: Saquinavir
Descriptor Portuguese: Saquinavir
Descriptor French: Saquinavir
Entry term(s): Invirase
Monomethanesulfonate, Saquinavir
Ro 31 8959
Ro 31-8959
Ro 318959
Saquinavir Mesylate
Saquinavir Monomethanesulfonate
Saquinivir
Tree number(s): D03.633.100.531.770
D03.633.100.810.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019258
Scope note: An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: HIV Protease Inhibitors
Cytochrome P-450 CYP3A Inhibitors
Registry Number: L3JE09KZ2F
Previous Indexing: HIV Protease/antagonists & inhibitors (1990-1992)
Isoquinolines (1993-1996)
Quinolines (1993-1996)
Public MeSH Note: 97; SAQUINAVIR was indexed under ISOQUINOLINES & QUINOLINES 1993-96 and HIV PROTEASE/antagonists & inhibitors 1990-92
Online Note: use SAQUINAVIR (NM) to search SAQUINAVIR 1990-96
History Note: 97; was SAQUINAVIR (NM) 1990-96
DeCS ID: 32996
Unique ID: D019258
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2016/05/31
Saquinavir - Preferred
Concept UI M0028681
Scope note An HIV protease inhibitor which acts as an analog of an HIV protease cleavage site. It is a highly specific inhibitor of HIV-1 and HIV-2 proteases, and also inhibits CYTOCHROME P-450 CYP3A.
Preferred term Saquinavir
Entry term(s) Saquinivir
Ro 31-8959 - Narrower
Concept UI M0353770
Preferred term Ro 31-8959
Entry term(s) Ro 31 8959
Ro 318959
Saquinavir Monomethanesulfonate - Narrower
Concept UI M0329184
Preferred term Saquinavir Monomethanesulfonate
Entry term(s) Monomethanesulfonate, Saquinavir
Saquinavir Mesylate
Invirase - Narrower
Concept UI M0353771
Preferred term Invirase



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