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Descriptor in English: Signal Transduction
Descriptor in Spanish: Transducción de Señal
Descriptor in Portuguese: Transdução de Sinais
Descriptor in French: Transduction du signal
Entry term(s): Cell Signaling
Pathway, Signal
Pathway, Signal Transduction
Pathways, Signal
Pathways, Signal Transduction
Receptor Mediated Signal Transduction
Receptor-Mediated Signal Transduction
Receptor-Mediated Signal Transductions
Signal Pathway
Signal Pathways
Signal Transduction Pathway
Signal Transduction Pathways
Signal Transduction System
Signal Transduction Systems
Signal Transduction, Receptor-Mediated
Signal Transductions
Signal Transductions, Receptor-Mediated
System, Signal Transduction
Systems, Signal Transduction
Transduction, Signal
Transductions, Signal
Tree number(s): G02.111.820
G04.835
Scope note: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
History Note: 89
See also the descriptors: Ion Channels MeSH
DeCS UI: 23827
Descriptor UI: D015398
Date Established: 1989/01/01
Date of Entry: 1988/06/06
Revision Date: 2019/07/05
Signal Transduction - Preferred
Concept UI M0023729
Scope note The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Preferred term Signal Transduction
Entry term(s) Cell Signaling
Signal Transduction System
Signal Transduction Systems
Signal Transductions
System, Signal Transduction
Systems, Signal Transduction
Transduction, Signal
Transductions, Signal
Signal Pathways - Narrower
Concept UI M0023728
Preferred term Signal Pathways
Entry term(s) Pathway, Signal
Pathways, Signal
Signal Pathway
Signal Transduction Pathways - Narrower
Concept UI M0023730
Preferred term Signal Transduction Pathways
Entry term(s) Pathway, Signal Transduction
Pathways, Signal Transduction
Signal Transduction Pathway
Receptor-Mediated Signal Transduction - Narrower
Concept UI M0023727
Preferred term Receptor-Mediated Signal Transduction
Entry term(s) Receptor Mediated Signal Transduction
Receptor-Mediated Signal Transductions
Signal Transduction, Receptor-Mediated
Signal Transductions, Receptor-Mediated



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