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Descriptor English: Bosentan
Descriptor Spanish: Bosentán
Descriptor Portuguese: Bosentana
Descriptor French: Bosentan
Entry term(s): 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Bosentan Anhydrous
Bosentan Monohydrate
Ro 47 0203
Ro 47-0203
Ro 470203
Ro-47-0203
Tracleer
Tree number(s): D02.065.884.135
D02.886.590.700.143
D03.383.742.060
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077300
Scope note: A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Endothelin Receptor Antagonists
Registry Number: Q326023R30
CAS Type 1 Name: Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)-
Public MeSH Note: 2019; BOSENTAN was indexed under SULFONAMIDES 1995-2018; and under RECEPTORS, ENDOTHELIN/antagonists 1994
History Note: 2019 (1994)
DeCS ID: 57600
Unique ID: D000077300
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27
Bosentan - Preferred
Concept UI M000640413
Scope note A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.
Preferred term Bosentan
Entry term(s) 4-t-Butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
Bosentan Monohydrate - Narrower
Concept UI M000637175
Preferred term Bosentan Monohydrate
Tracleer - Narrower
Concept UI M0413789
Preferred term Tracleer
Bosentan Anhydrous - Narrower
Concept UI M0585634
Preferred term Bosentan Anhydrous
Ro 47-0203 - Narrower
Concept UI M0228617
Preferred term Ro 47-0203
Entry term(s) Ro 47 0203
Ro 470203
Ro-47-0203



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