| Descriptor English: | Complement C3 Nephritic Factor | ||||||
| Descriptor Spanish: |
Factor Nefrítico del Complemento 3
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| Descriptor Portuguese: | Fator Nefrítico do Complemento 3 | ||||||
| Descriptor French: | Facteur néphritique C3 | ||||||
| Entry term(s): |
C 3 Nephritic Factor C3 NeF C3 NeF IgG Autoantibodies C3 NeF IgG Autoantibody C3 Nephritic Factor C3NeF IgG Autoantibodies C3NeF IgG Autoantibody Complement 3 Nephritic Factor |
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| Tree number(s): |
D12.776.124.486.274.920.287 D12.776.124.486.485.114.323.300 D12.776.124.790.651.114.323.300 D12.776.377.715.548.114.323.300 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D003178 | ||||||
| Scope note: | An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Immunologic Factors Complement Inactivating Agents |
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| Previous Indexing: |
Blood Proteins (1966-1977) Complement 3 (1975-1977) |
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| Public MeSH Note: | 2006; see COMPLEMENT 3 NEPHRITIC FACTOR 1991-2005, see COMPLEMENT INACTIVATORS 1978-1990 |
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| History Note: | 2006 (1978) |
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| DeCS ID: | 22147 | ||||||
| Unique ID: | D003178 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1977/05/20 | ||||||
| Revision Date: | 2009/07/30 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Complement C3 Nephritic Factor
- Preferred
| Concept UI |
M0004930 |
| Scope note | An IgG autoantibody against the ALTERNATIVE PATHWAY C3 CONVERTASE, found in serum of patients with MESANGIOCAPILLARY GLOMERULONEPHRITIS. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (COMPLEMENT FACTOR H; COMPLEMENT FACTOR I). This abnormally stabilized enzyme induces a continuous COMPLEMENT ACTIVATION and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis. |
| Preferred term | Complement C3 Nephritic Factor |
| Entry term(s) |
C 3 Nephritic Factor C3 NeF C3 NeF IgG Autoantibodies C3 NeF IgG Autoantibody C3 Nephritic Factor C3NeF IgG Autoantibodies C3NeF IgG Autoantibody Complement 3 Nephritic Factor |
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