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Descriptor English: RNA Caps
Descriptor Spanish: Caperuzas de ARN
Descriptor Portuguese: Capuzes de RNA
Descriptor French: Coiffes des ARN
Entry term(s): 5' Capped RNA
5' mRNA Cap Structure
Caps, RNA
RNA, 5' Capped
Tree number(s): D03.633.100.759.646.454.700
D13.444.735.544.500
D13.695.667.454.700
D13.695.827.426.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012315
Scope note: Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Annotation: IM; /drug eff /ultrastruct permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: analogs & derivatives:RNA Cap Analogs
Previous Indexing: Guanine Nucleotides (1966-1971)
Guanosine Triphosphate (1972-1974)/analogs & derivatives (1975-1979)
Oligoribonucleotides (1976-1979)
RNA, Messenger (1966-1979)
Ribonucleotides (1971-1975)
Public MeSH Note: 80
History Note: 80
DeCS ID: 22278
Unique ID: D012315
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1979/05/23
Revision Date: 2016/05/31
RNA Caps - Preferred
Concept UI M0019141
Scope note Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.
Preferred term RNA Caps
Entry term(s) 5' Capped RNA
5' mRNA Cap Structure
Caps, RNA
RNA, 5' Capped



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