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Descriptor English: Pyruvate Decarboxylase
Descriptor Spanish: Piruvato Descarboxilasa
Descriptor piruvato descarboxilasa
Entry term(s) 2-oxoácido carboxiliasa
alfa-carboxilasa
alfa-cetoácido carboxilasa
descarboxilasa pirúvica
pirúvico descarboxilasa
Scope note: Cataliza la descarboxilación de un alfa cetoácido formando un aldehído y anhídrido carbónico. Un cofactor esencial es la tiamina pirofosfato. En organismos inferiores, que fermentan la glucosa a etanol y anhídrido carbónico, la enzima descarboxila irreversiblemente el piruvato a acetaldehído. EC 4.1.1.1.
Descriptor Portuguese: Piruvato Descarboxilase
Descriptor French: Pyruvate decarboxylase
Entry term(s): 2 Oxo Acid Carboxy Lyase
2-Oxo Acid Carboxy-Lyase
Acid Carboxy-Lyase, 2-Oxo
Carboxy-Lyase, 2-Oxo Acid
Carboxylase, alpha-Ketoacid
Decarboxylase, Pyruvate
Decarboxylase, Pyruvic
Pyruvic Decarboxylase
alpha Carboxylase
alpha Ketoacid Carboxylase
alpha-Carboxylase
alpha-Ketoacid Carboxylase
Tree number(s): D08.811.520.224.125.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011767
Scope note: Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.1.1.1
Previous Indexing: Carboxy-Lyases (1973-1974)
Pyruvates (1973-1974)
Public MeSH Note: 91; was see under CARBOXY-LYASES 1975-90
History Note: 91(75); was see under CARBOXY-LYASES 1975-90
DeCS ID: 22630
Unique ID: D011767
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
Pyruvate Decarboxylase - Preferred
Concept UI M0018289
Scope note Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
Preferred term Pyruvate Decarboxylase
Entry term(s) 2 Oxo Acid Carboxy Lyase
2-Oxo Acid Carboxy-Lyase
Acid Carboxy-Lyase, 2-Oxo
Carboxy-Lyase, 2-Oxo Acid
Carboxylase, alpha-Ketoacid
Decarboxylase, Pyruvate
Decarboxylase, Pyruvic
Pyruvic Decarboxylase
alpha Carboxylase
alpha Ketoacid Carboxylase
alpha-Carboxylase
alpha-Ketoacid Carboxylase



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