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Descriptor English: Glutamate Decarboxylase
Descriptor Spanish: Glutamato Descarboxilasa
Descriptor glutamato descarboxilasa
Entry term(s) glutamato carboxiliasa
Scope note: Proteína con fosfato de piridoxal, que cataliza la alfa-descarboxilación del ácido L-glutámico para formar ácido gamma-aminobutírico y anhídrido carbónico. La enzima se encuentra en bacterias y en el sistema nervioso de invertebrados y vertebrados. Es una enzima limitadora de la velocidad de reacción en la determinación de las concentraciones de GABA en el tejidos nervioso normal. La enzima cerebral también actúa sobre el L-cisteato, L-cisteína sulfinato y L-aspartato. EC 4.1.1.15.
Descriptor Portuguese: Glutamato Descarboxilase
Descriptor French: Glutamate decarboxylase
Entry term(s): Acid Decarboxylase, Glutamic
Carboxy-Lyase, Glutamate
Decarboxylase, Glutamate
Decarboxylase, Glutamic Acid
Glutamate Carboxy Lyase
Glutamate Carboxy-Lyase
Glutamic Acid Decarboxylase
Tree number(s): D08.811.520.224.125.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005968
Scope note: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.1.1.15
CAS Type 1 Name: L-Glutamate-1-carboxy-lyase
Previous Indexing: Carboxy-Lyases (1973-1974)
Glutamates (1973-1974)
Public MeSH Note: 84; was see under CARBOXY-LYASES 1975-83
History Note: 84(75); was see under CARBOXY-LYASES 1975-83
DeCS ID: 6112
Unique ID: D005968
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
Glutamate Decarboxylase - Preferred
Concept UI M0009373
Scope note A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
Preferred term Glutamate Decarboxylase
Entry term(s) Acid Decarboxylase, Glutamic
Carboxy-Lyase, Glutamate
Decarboxylase, Glutamate
Decarboxylase, Glutamic Acid
Glutamate Carboxy Lyase
Glutamate Carboxy-Lyase
Glutamic Acid Decarboxylase



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