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Descriptor English: Lymphocyte Activation
Descriptor Spanish: Activación de Linfocitos
Descriptor Portuguese: Ativação Linfocitária
Descriptor French: Activation des lymphocytes
Entry term(s): Activation, Lymphocyte
Blast Transformation
Blastogenesis
Lymphoblast Transformation
Lymphocyte Stimulation
Lymphocyte Transformation
Stimulation, Lymphocyte
Transformation, Blast
Transformation, Lymphoblast
Transformation, Lymphocyte
Tree number(s): E01.370.225.812.482
E05.200.812.482
E05.478.594.530
G12.450.050.400.545
G12.565
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008213
Scope note: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Annotation: lymphocyte transformation test goes here but do not index under specific agent inducing transformation unless particularly discussed; do not use for neoplastic transformation of lymphocytes ( = CELL TRANSFORMATION, NEOPLASTIC) or viral transformation of lymphocytes ( = CELL TRANSFORMATION, VIRAL); blast transformation in chronic myelogenous leukemia does not go here: index BLAST CRISIS; DF: LYMPHOCYTE TRANSFORM
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Lymphocytes/immunology (1966-1968)
Public MeSH Note: 2003; see LYMPHOCYTE TRANSFORMATION 1972-2002; for BLAST TRANSFORMATION see BLAST CRISIS 1987-1992
History Note: 2003 (1969); for BLAST TRANSFORMATION use BLAST CRISIS 1987-1992
Related: Blast Crisis MeSH
DeCS ID: 23302
Unique ID: D008213
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/23
Lymphocyte Activation - Preferred
Concept UI M0012805
Scope note Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Preferred term Lymphocyte Activation
Entry term(s) Activation, Lymphocyte
Blast Transformation
Blastogenesis
Lymphoblast Transformation
Lymphocyte Stimulation
Lymphocyte Transformation
Stimulation, Lymphocyte
Transformation, Blast
Transformation, Lymphoblast
Transformation, Lymphocyte



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