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Descriptor English: Immunoglobulin Switch Region
Descriptor Spanish: Región de Cambio de la Inmunoglobulina
Descriptor región de cambio de las inmunoglobulinas
Entry term(s) región de cambio de las Ig
región de conmutación de inmunoglobulinas
Scope note: Sitio localizado en los INTRONES en el extremo 5' de cada segmento de región constante de un gen de la cadena pesada de la inmunoglobulina donde se produce la recombinación (o el reordenamiento) durante el CAMBIO DE CLASE DE LAS INMUNOGLOBULINAS. Las regiones de cambio de las inmunoglobulinas se encuentran en genes que codifican las cinco clases (ISOTIPOS DE INMUNOGLOBULINAS) de las CADENAS PESADAS DE LAS INMUNOGLOBULINAS.
Descriptor Portuguese: Região de Troca de Imunoglobulinas
Descriptor French: Région switch des immunoglobulines
Entry term(s): Heavy-Chain Mu Switch Region
Ig Switch Region
Ig Switch Regions
Ig Switch Sequence
Ig Switch Sequences
Immunoglobulin Switch Regions
Region, Ig Switch
Region, Immunoglobulin Switch
Regions, Ig Switch
Regions, Immunoglobulin Switch
Sequence, Ig Switch
Sequences, Ig Switch
Switch Region, Ig
Switch Region, Immunoglobulin
Switch Regions, Ig
Switch Regions, Immunoglobulin
Switch Sequence, Ig
Switch Sequences, Ig
Tree number(s): G05.360.340.024.340.137.430
G05.360.340.024.340.335.300.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007134
Scope note: A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
IP isolation & purification
PH physiology
RE radiation effects
Previous Indexing: Genes, Structural (1977-1987)
Immunoglobulin Constant Region (1979-1987)
Immunoglobulin Variable Region (1977-1987)
Public MeSH Note: 88
History Note: 88
Entry Version: IG SWITCH REGION
Related: Immunoglobulin Class Switching MeSH
DeCS ID: 24263
Unique ID: D007134
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/05/11
Revision Date: 2019/07/05
Immunoglobulin Switch Region - Preferred
Concept UI M0011115
Scope note A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
Preferred term Immunoglobulin Switch Region
Entry term(s) Ig Switch Region
Ig Switch Regions
Ig Switch Sequence
Ig Switch Sequences
Immunoglobulin Switch Regions
Region, Ig Switch
Region, Immunoglobulin Switch
Regions, Ig Switch
Regions, Immunoglobulin Switch
Sequence, Ig Switch
Sequences, Ig Switch
Switch Region, Ig
Switch Region, Immunoglobulin
Switch Regions, Ig
Switch Regions, Immunoglobulin
Switch Sequence, Ig
Switch Sequences, Ig
Heavy-Chain Mu Switch Region - Narrower
Concept UI M0011114
Preferred term Heavy-Chain Mu Switch Region



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