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Descriptor English: alpha 1-Antichymotrypsin
Descriptor Spanish: alfa 1-Antiquimotripsina
Descriptor alfa 1-antiquimotripsina
Scope note: Glicoproteína que se encuentra en la región alfa(1)-globulina del suero humano. Inhibe las proteinasas similares a quimotripsina y tiene una actividad citotóxica in vitro. La proteína tiene también un papel como proteína de fase aguda y es activa en el control de los procesos inmunológicos e inflamatorios y como marcador tumoral. Es miembro de la superfamilia de las serpinas.
Descriptor Portuguese: alfa 1-Antiquimotripsina
Descriptor French: alpha-1-Antichymotrypsine
Entry term(s): Serpin A3
alpha 1 Antichymotrypsin
alpha(1)-Antichymotrypsin
Tree number(s): D09.400.430.563
D12.644.861.030
D12.776.124.050.050
D12.776.124.790.106.050
D12.776.377.715.085.050
D12.776.395.045
D12.776.872.030
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000514
Scope note: Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Serine Proteinase Inhibitors
Previous Indexing: Chymotrypsin/antagonists & inhibitors (1968-1986)
Glycoproteins (1966-1986)
Protease Inhibitors (1979-1986)
Public MeSH Note: 87
History Note: 87
DeCS ID: 27943
Unique ID: D000514
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/04/14
Revision Date: 2015/06/23
alpha 1-Antichymotrypsin - Preferred
Concept UI M0000778
Scope note Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
Preferred term alpha 1-Antichymotrypsin
Entry term(s) Serpin A3
alpha 1 Antichymotrypsin
alpha(1)-Antichymotrypsin



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