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Descriptor English: Peptide T
Descriptor Spanish: Péptido T
Descriptor péptido T
Entry term(s) péptido T del VIH
Scope note: N-(N-(N(2)-(N-(N-(N-(N-D-Alanil L-seril)-L-treonil)-L-treonil) L-treonil)-L-asparaginil)-L-tirosil) L-treonina. Octapéptido que comparte la homología de secuencias con la proteína de envoltura gp120 del VIH. Es potencialmente útil como antivírico en el tratamiento del SIDA. La secuencia pentapeptídica de la porción central, TTNYT, que consta de aminoácidos 4-8 en el péptido T, es la secuencia de la envoltura del VIH requerida para la unión al receptor CD4.
Descriptor Portuguese: Peptídeo T
Descriptor French: Peptide T
Entry term(s): HIV Peptide T
Peptide T, HIV
Tree number(s): D12.644.456.729
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015717
Scope note: N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
Annotation: /biosyn /drug eff /physiol permitted
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 106362-33-8
CAS Type 1 Name: L-Threonine, N-(N-(N2-(N-(N-(N-(N-D-alanyl-L-seryl)-L-threonyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-
Previous Indexing: Oligopeptides (1987-1989)
Peptide Fragments (1987-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24831
Unique ID: D015717
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 1990/06/29
Peptide T - Preferred
Concept UI M0024099
Scope note N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
Preferred term Peptide T
Entry term(s) HIV Peptide T
Peptide T, HIV



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