DeCS

Descriptor English:

Tuftsin

Descriptor Spanish:

Tuftsina

Spanish from Spain

Descriptor	tuftsina
Scope note:	N(2)-((1-(N(2)-L-treonil)-L-lisil)-L-prolil)-L-arginina. Tetrapéptido producido en el bazo por desdoblamiento enzimático de una gammaglobulina leucofílica. Estimula la actividad fagocítica de los leucocitos polimorfonucleares de la sangre, sobre todo de los neutrófilos. El péptido se localiza en el fragmento Fd de la molécula de gamma globulina.

Descriptor Portuguese:

Tuftsina

Descriptor French:

Tuftsine

Entry term(s):

L-Thr-L-Lys-L-Pro-L-Arg
L-Threonyl-L-Lysyl-L-Prolyl-L-Arginine
Taftsin

Tree number(s):

D12.644.456.840
D12.644.541.500.650.750
D12.776.124.486.485.397.500
D12.776.124.486.485.680.650.750
D12.776.124.790.651.397.500
D12.776.124.790.651.680.650.750
D12.776.377.715.548.397.500
D12.776.377.715.548.680.650.750

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D014405

Scope note:

N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Allowable Qualifiers:

AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine

Pharm Action:

Immunologic Factors

Registry Number:

QF5336J16C

CAS Type 1 Name:

L-Arginine, N2-(1-(N2-L-threonyl-L-lysyl)-L-prolyl)-

Previous Indexing:

Immunoglobulin Fragments (1973-1974)
Oligopeptides (1973-1974)

Public MeSH Note:

84; was see under IMMUNOGLOBULINS, FD 1975-83; LEUKOKININ (with LEUCOKININ a see ref to it) was see under GAMMA GLOBULINS 1975-83; LEUKOKININ & LEUCOKININ were see TUFTSIN 1984-93

Online Note:

use TUFTSIN to search LEUKOKININ & LEUCOKININ 1975-93

History Note:

84(75); was see under IMMUNOGLOBULINS, FD 1975-83; LEUKOKININ (with LEUCOKININ a see ref to it) was see under GAMMA GLOBULINS 1975-83; LEUKOKININ & LEUCOKININ were see TUFTSIN 1984-93

Concept UI	M0022144
Scope note	N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.
Preferred term	Tuftsin
Entry term(s)	L-Thr-L-Lys-L-Pro-L-Arg L-Threonyl-L-Lysyl-L-Prolyl-L-Arginine Taftsin

We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.