DeCS

Descriptor English:

Novobiocin

Descriptor Spanish:

Novobiocina

Spanish from Spain

Descriptor	novobiocina
Entry term(s)	estreptonivicina ácido cristalínico
Scope note:	Compuesto antibiótico derivado de Streptomyces niveus. Tiene una estructura química similar a la cumarina. La novobiocina se une a la ADN girasa y bloquea la actividad de la adenosina trifosfatasa (ATPasa). (Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189).

Descriptor Portuguese:

Novobiocina

Descriptor French:

Novobiocine

Entry term(s):

Novobiocine calcique
Novobiocine de calcium
Novobiocine de sodium
Novobiocine sodique

Tree number(s):

D03.383.663.283.446.139.500
D03.633.100.150.446.139.500
D09.408.554

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D009675

Scope note:

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Anti-Bacterial Agents
Enzyme Inhibitors
Nucleic Acid Synthesis Inhibitors

Registry Number:

17EC19951N

CAS Type 1 Name:

Benzamide, N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)-

DeCS ID:

28212

Unique ID:

D009675

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1966/01/01

Date of Entry:

1999/01/01

Revision Date:

2016/05/31