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Descriptor English: Lymphocyte Function-Associated Antigen-1
Descriptor Spanish: Antígeno-1 Asociado a Función de Linfocito
Descriptor antígeno-1 asociado a la función del linfocito
Entry term(s) LFA-1
antígeno-1 asociado a la función del leucocito
antígeno-1 asociado a la función linfocitaria
Scope note: Integrina heterodimérica ampliamente presente en células de origen hematopoyético. El ANTÍGENO CD11A contiene la cadena alfa y el antígeno CD18 (ANTÍGENOS CD18) la cadena beta. El antigeno-1 de función asociada de linfocito es un importante receptor de las CÉLULAS T, CÉLULAS B y GRANULOCITOS. Es mediador de las reacciones de adhesión de los leucocitos que intervienen en la formación de conjugados citolíticos, interacciones de las células T auxiliares y la muerte celular dependiente de los anticuerpos por las CÉLULAS KILLER NATURALES y los granulocitos. La MOLÉCULA 1 DE ADHESIÓN INTERCELULAR (ICAM-1) se ha definido como un ligando para el antigeno-1 de función asociada de linfocito.
Descriptor Portuguese: Antígeno-1 Associado à Função Linfocitária
Descriptor French: Antigène-1 associé à la fonction du lymphocyte
Entry term(s): Antigen-1, Lymphocyte Function-Associated
Integrin alphaLbeta2
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
alphaLbeta2, Integrin
Tree number(s): D12.776.395.550.200.074.937
D12.776.395.550.200.625.550
D12.776.543.550.200.093.937
D12.776.543.550.200.625.550
D12.776.543.750.705.408.600.400
D12.776.543.750.705.877.550
D23.050.301.350.074.400
D23.050.301.350.625.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016169
Scope note: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antigens, Differentiation (1988-1990)
Receptors, Leukocyte-Adhesion (1989-1990)
Public MeSH Note: 1991
History Note: 1991
Entry Version: LFA1
DeCS ID: 29009
Unique ID: D016169
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2017/07/13
Lymphocyte Function-Associated Antigen-1 - Preferred
Concept UI M0024683
Scope note An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Preferred term Lymphocyte Function-Associated Antigen-1
Entry term(s) Antigen-1, Lymphocyte Function-Associated
Integrin alphaLbeta2
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
alphaLbeta2, Integrin



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