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Descriptor English: Maturation-Promoting Factor
Descriptor Spanish: Factor Promotor de Maduración
Descriptor Portuguese: Fator Promotor de Maturação
Descriptor French: Facteur de promotion de la maturation
Entry term(s): Histone H1 Kinase, Growth Associated
Histone H1 Kinase, Growth-Associated
Histone H1 Kinase, M Phase Specific
Histone H1 Kinase, M-Phase-Specific
M Phase Promoting Factor
M Phase-Promoting Factor
Maturation Promoting Factor
Mitosis Promoting Factor
Mitosis-Promoting Factor
Tree number(s): D08.811.913.696.620.682.700.646.500.984
D12.644.360.250.580
D12.776.167.200.580
D12.776.476.250.580
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016200
Scope note: Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: EC 2.7.11.22
Previous Indexing: Growth Substances (1979-1990)
Public MeSH Note: 91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
History Note: 91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93
Entry Version: MPF
Related: Cyclins MeSH
DeCS ID: 29039
Unique ID: D016200
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/06/17
Revision Date: 2015/11/24
Maturation-Promoting Factor - Preferred
Concept UI M0024733
Scope note Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
Preferred term Maturation-Promoting Factor
Entry term(s) Histone H1 Kinase, Growth Associated
Histone H1 Kinase, Growth-Associated
Histone H1 Kinase, M Phase Specific
Histone H1 Kinase, M-Phase-Specific
M Phase Promoting Factor
M Phase-Promoting Factor
Maturation Promoting Factor
Mitosis Promoting Factor
Mitosis-Promoting Factor



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