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Descriptor English: Cyclin-Dependent Kinase 2
Descriptor Spanish: Quinasa 2 Dependiente de la Ciclina
Descriptor cinasa 2 dependiente de la ciclina
Entry term(s) proteincinasa Cdk2
proteína cinasa Cdk2
proteína-cinasa Cdk2
Scope note: Regulador clave de la progresión del CICLO CELULAR. Se asocia a la CICLINA E para regular la entrada en la FASE S e interactúa también con la CICLINA A en la fosforilación de la PROTEÍNA DEL RETINOBLASTOMA. Su actividad es inhibida por el INHIBIDOR P27 DE CINASA DEPENDIENTE DE LA CICLINA y por el INHIBIDOR P21 DE CINASA DEPENDIENTE DE LA CICLINA.
Descriptor Portuguese: Quinase 2 Dependente de Ciclina
Descriptor French: Kinase-2 cycline-dépendante
Entry term(s): CDK2 Protein
Cdc2 Related Protein Kinase
Cdc2-Related Protein Kinase
Cdk2 Protein Kinase
Cyclin Dependent Kinase 2
p33cdk2 Kinase
Tree number(s): D08.811.913.696.620.682.700.646.500.750
D12.776.167.200.323
D12.776.476.563.646.500.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D051357
Scope note: A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.22
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE 2 was indexed under CDC2-CDC28 KINASES 2004-2005, & under CYCLIN-DEPENDENT KINASES 1991-2003, & under PROTEIN KINASES 1991-1994
History Note: 2006(1991)
DeCS ID: 50714
Unique ID: D051357
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23
Cyclin-Dependent Kinase 2 - Preferred
Concept UI M0191671
Scope note A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
Preferred term Cyclin-Dependent Kinase 2
Entry term(s) CDK2 Protein
Cdc2 Related Protein Kinase
Cdc2-Related Protein Kinase
Cdk2 Protein Kinase
Cyclin Dependent Kinase 2
p33cdk2 Kinase



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