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Descriptor English: Pepsin A
Descriptor Spanish: Pepsina A
Descriptor pepsina A
Entry term(s) pepsina
Scope note: Enzima formada a partir del pepsinógeno de cerdo por escisión de un enlace peptídico. Está formada por una cadena polipeptídica única y es inhibida por el metil 2 diaazoacetamidohexanoato. Escinde péptidos preferentemente en los enlaces carbonilo de la fenilanina o la leucina y es la principal enzima digestiva del jugo gástrico.
Descriptor Portuguese: Pepsina A
Descriptor French: Pepsine A
Entry term(s): Pepsin
Pepsin 1
Pepsin 3
Tree number(s): D08.811.277.656.074.500.700
D08.811.277.656.300.048.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010434
Scope note: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Annotation: /biosyn /physiol permitted
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Gastrointestinal Agents
Registry Number: EC 3.4.23.1
Public MeSH Note: 91; was PEPSIN 1964-90
Online Note: use PEPSIN A to search PEPSIN 1966-90
History Note: 91; was PEPSIN 1964-90
DeCS ID: 29296
Unique ID: D010434
NLM Classification: QV 66
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/06
Pepsin A - Preferred
Concept UI M0016204
Scope note Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Preferred term Pepsin A
Entry term(s) Pepsin
Pepsin 3 - Narrower
Concept UI M0016206
Preferred term Pepsin 3
Pepsin 1 - Narrower
Concept UI M0016205
Preferred term Pepsin 1



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