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Descriptor English: Renin
Descriptor Spanish: Renina
Descriptor Portuguese: Renina
Descriptor French: Rénine
Entry term(s): Angiotensin Forming Enzyme
Angiotensin-Forming Enzyme
Angiotensinogenase
Big Renin
Cryorenin
Inactive Renin
Pre Prorenin
Pre-Prorenin
Preprorenin
Prorenin
Renin, Big
Renin, Inactive
Tree number(s): D08.811.277.656.074.500.780
D08.811.277.656.300.048.780
D08.811.277.656.837.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012083
Scope note: A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
Annotation: do not confuse with RENNIN see CHYMOSIN
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.23.15
Public MeSH Note: 1963; PRORENIN was listed under ENZYME PRECUSORS & RENIN 1977-2003; PREPRORENIN was listed under ENZYME PRECUSORS & RENIN 1980-2003
History Note: 1963; for PRORENIN use RENIN (NM) 1977-2003, for PREPRORENIN use RENIN (NM) 1980-2003
DeCS ID: 29553
Unique ID: D012083
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1963/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/06
Renin - Preferred
Concept UI M0018776
Scope note A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
Preferred term Renin
Entry term(s) Angiotensin Forming Enzyme
Angiotensin-Forming Enzyme
Angiotensinogenase
Prorenin - Narrower
Concept UI M0061608
Preferred term Prorenin
Entry term(s) Big Renin
Cryorenin
Inactive Renin
Renin, Big
Renin, Inactive
Preprorenin - Narrower
Concept UI M0082816
Preferred term Preprorenin
Entry term(s) Pre Prorenin
Pre-Prorenin



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