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Descriptor English: Rioprostil
Descriptor Spanish: Rioprostilo
Descriptor rioprostilo
Scope note: Análogo sintético de la metilprostaglandina E1 que reduce la secreción de ácido gástrico y aumenta la barrera gástrica de moco y bicarbonato. Es eficaz en el tratamiento de las úlceras gástricas y brinda una protección significativa frente al daño en la mucosa gástrica inducido por los antiinflamatorios no esteroideos. Este fármaco previene también el daño inducido por la ciclosporina A sobre las secreciones pancreáticas endocrinas y exocrinas. Muestra un bajo nivel de toxicidad aguda y no hay datos de embriotoxicidad, fetotoxicidad, teratogenicidad, o mutagenicidad en estudios con animales.
Descriptor Portuguese: Rioprostila
Descriptor French: Rioprostil
Entry term(s): ORF 15927
ORF-15927
ORF15927
RWJ 15927
RWJ-15927
RWJ15927
TR 4698
TR-4698
TR4698
Tree number(s): D10.251.355.255.550.775.450.750
D23.469.050.175.725.775.450.750
D23.469.700.660.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016630
Scope note: A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Ulcer Agents
Registry Number: 7JL402PVQR
CAS Type 1 Name: Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-
Previous Indexing: Anti-Ulcer Agents (1977-1991)
Prostaglandins E (1975-1991)
Prostaglandins, Synthetic (1977-1991)
Public MeSH Note: 92; RIOPROSTIL was indexed under PROSTAGLANDINS E 1985-91
Online Note: use RIOPROSTIL (NM) to search RIOPROSTIL 1985-91
History Note: 92; was RIOPROSTIL (NM) 1985-91
DeCS ID: 29838
Unique ID: D016630
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2015/06/08
Rioprostil - Preferred
Concept UI M0025346
Scope note A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.
Preferred term Rioprostil
TR-4698 - Narrower
Concept UI M0351569
Preferred term TR-4698
Entry term(s) TR 4698
TR4698
ORF-15927 - Narrower
Concept UI M0351571
Preferred term ORF-15927
Entry term(s) ORF 15927
ORF15927
RWJ-15927 - Narrower
Concept UI M0351570
Preferred term RWJ-15927
Entry term(s) RWJ 15927
RWJ15927



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