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Descriptor English: Rioprostil
Descriptor Spanish: Rioprostilo
Descriptor rioprostilo
Scope note: Análogo sintético de la metilprostaglandina E1 que reduce la secreción de ácido gástrico y aumenta la barrera gástrica de moco y bicarbonato. Es eficaz en el tratamiento de las úlceras gástricas y brinda una protección significativa frente al daño en la mucosa gástrica inducido por los antiinflamatorios no esteroideos. Este fármaco previene también el daño inducido por la ciclosporina A sobre las secreciones pancreáticas endocrinas y exocrinas. Muestra un bajo nivel de toxicidad aguda y no hay datos de embriotoxicidad, fetotoxicidad, teratogenicidad, o mutagenicidad en estudios con animales.
Descriptor Portuguese: Rioprostila
Descriptor French: Rioprostil
Entry term(s): ORF-15927
RWJ-15927
TR-4698
Tree number(s): D10.251.355.255.550.775.450.750
D23.469.050.175.725.775.450.750
D23.469.700.660.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016630
Scope note: A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Pharm Action: Anti-Ulcer Agents
Registry Number: 7JL402PVQR
CAS Type 1 Name: Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-
DeCS ID: 29838
Unique ID: D016630
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/25
Revision Date: 2015/06/08
Rioprostil - Preferred
Concept UI M0025346
Preferred term Rioprostil
TR-4698 - Narrower
Concept UI M0351569
Preferred term TR-4698
ORF-15927 - Narrower
Concept UI M0351571
Preferred term ORF-15927
RWJ-15927 - Narrower
Concept UI M0351570
Preferred term RWJ-15927



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