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Descriptor English: Cellular Senescence
Descriptor Spanish: Senescencia Celular
Descriptor senescencia celular
Entry term(s) envejecimiento celular
envejecimiento de la célula
senescencia de la célula
senescencia replicadora
Scope note: Disminución, con el paso del tiempo, de la capacidad proliferativa de las células. Cada célula está programada para realizar determinado número de divisiones celulares y, al finalizar dicho tiempo, la proliferación se interrumpe y la célula entra en un estado de inactividad tras el cual se produce la MUERTE CELULAR a través del proceso de APOPTOSIS.
Descriptor Portuguese: Senescência Celular
Descriptor French: Vieillissement de la cellule
Entry term(s): Ageing, Cell
Ageing, Cellular
Aging, Cell
Aging, Cellular
Cell Ageing
Cell Aging
Cell Senescence
Cellular Ageing
Cellular Aging
Replicative Senescence
Senescence, Cell
Senescence, Cellular
Senescence, Replicative
Tree number(s): G04.043
G07.345.124.130
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016922
Scope note: Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
Annotation: not for micro-organisms
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Cell Survival (1977-1991)
Erythrocyte Aging (1967-1991)
Public MeSH Note: 2018; see CELL AGING 1992-2017; see CELL SURVIVAL 1977-1991; for CELL SENESCENCE and SENESCENCE, CELLULAR see CELL SURVIVAL 1991
History Note: 2018 (1992); use CELL SURVIVAL 1977-1991
Related: Cell Death MeSH
DeCS ID: 30205
Unique ID: D016922
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2017/06/22
Cellular Senescence - Preferred
Concept UI M0025749
Scope note Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
Preferred term Cellular Senescence
Entry term(s) Cell Senescence
Senescence, Cell
Senescence, Cellular
Cell Aging - Narrower
Concept UI M000630817
Scope note Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals.
Preferred term Cell Aging
Entry term(s) Ageing, Cell
Ageing, Cellular
Aging, Cell
Aging, Cellular
Cell Ageing
Cellular Ageing
Cellular Aging
Replicative Senescence
Senescence, Replicative



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