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Descriptor in English: Clotrimazole
Descriptor in Spanish: Clotrimazol
Descriptor in Portuguese: Clotrimazol
Descriptor in French: Clotrimazole
Entry term(s): Bay b 5097
Canesten
FB b 5097
Kanesten
Klotrimazole
Lotrimin
Mycelex
Tree number(s): D03.383.129.308.175
Scope note: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 91(75); was see under IMIDAZOLES 1975-90
DeCS UI: 3049
Descriptor UI: D003022
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2017/05/24
Clotrimazole - Preferred
Concept UI M0004642
Scope note An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Preferred term Clotrimazole
Entry term(s) Klotrimazole
Mycelex - Narrower
Concept UI M0004646
Preferred term Mycelex
FB b 5097 - Narrower
Concept UI M0353210
Preferred term FB b 5097
Lotrimin - Narrower
Concept UI M0004645
Preferred term Lotrimin
Bay b 5097 - Narrower
Concept UI M0353209
Preferred term Bay b 5097
Canesten - Narrower
Concept UI M0004643
Preferred term Canesten
Entry term(s) Kanesten



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