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Descriptor English: Levamisole
Descriptor Spanish: Levamisol
Descriptor levamisol
Entry term(s) L-tetramisol
levotetramisol
Scope note: Fármaco antihelmíntico que se ha utilizado experimentalmente para el tratamiento de enfermedades reumáticas, dado que aparentemente restaura la respuesta inmune al incrementar la quimiotaxia de los macrófagos y la función de los linfocitos T. Paradójicamente, esta mejora inmune parace ser beneficiosa en la artritis reumatoide, habiendose informado efectos secundarios tales como dermatitis, leucopenia y trombocitopenia, nauseas y vómitos.
Descriptor Portuguese: Levamisol
Descriptor French: Lévamisole
Entry term(s): Decaris
Dekaris
Hydrochloride, Levamisole
L-Tetramisole
Levamisole Hydrochloride
Levotetramisole
Solaskil
Tree number(s): D02.886.675.346
D03.383.129.308.480
D03.383.129.708.346
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007978
Scope note: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adjuvants, Immunologic
Antinematodal Agents
Antirheumatic Agents
Registry Number: 2880D3468G
CAS Type 1 Name: Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-, (S)-
Public MeSH Note: 74
History Note: 74
DeCS ID: 28126
Unique ID: D007978
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Levamisole - Preferred
Concept UI M0012431
Scope note An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Preferred term Levamisole
Entry term(s) L-Tetramisole
Levotetramisole
Levamisole Hydrochloride - Narrower
Concept UI M0330203
Preferred term Levamisole Hydrochloride
Entry term(s) Hydrochloride, Levamisole
Solaskil - Narrower
Concept UI M0353243
Preferred term Solaskil
Dekaris - Narrower
Concept UI M0012432
Preferred term Dekaris
Entry term(s) Decaris



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