PHENOMENA AND PROCESSES      Cell Physiological Phenomena [G04]      Cell Physiological Phenomena           Cell Death [G04.146]           Cell Death                Regulated Cell Death [G04.146.954]                Regulated Cell Death                     Apoptosis [G04.146.954.035] +                     Apoptosis +                          Anoikis [G04.146.954.035.060]                          Anoikis                          Eryptosis [G04.146.954.035.295]                          Eryptosis                          Pyroptosis [G04.146.954.035.530]                          Pyroptosis                     Autophagic Cell Death [G04.146.954.053]                     Autophagic Cell Death                     Ferroptosis [G04.146.954.178]                     Ferroptosis                     Immunogenic Cell Death [G04.146.954.285]                     Immunogenic Cell Death                     Mitochondrial Transmembrane Permeability Driven Necrosis [G04.146.954.393]                     Mitochondrial Transmembrane Permeability Driven Necrosis                     Necroptosis [G04.146.954.500]                     Necroptosis                     Parthanatos [G04.146.954.750]                     Parthanatos

Apoptosis - Preferred

Concept UI	M0026116
Scope note	A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically-programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Preferred term	Apoptosis
Entry term(s)	Apoptosis, Classic Apoptosis, Classical Classic Apoptoses Classic Apoptosis Classical Apoptosis Programmed Cell Death, Type I

Apoptosis, Intrinsic Pathway - Narrower

Concept UI	M0493497
Scope note	Apoptosis that is triggered via cell stress and mitochondrial damage.
Preferred term	Apoptosis, Intrinsic Pathway
Entry term(s)	Apoptoses, Intrinsic Pathway Intrinsic Pathway Apoptoses Intrinsic Pathway Apoptosis

Apoptosis, Extrinsic Pathway - Narrower

Concept UI	M0493496
Scope note	Apoptosis that is triggered via CELL SURFACE RECEPTORS such as TUMOR NECROSIS FACTOR RECEPTORS and DEATH DOMAIN RECEPTORS.
Preferred term	Apoptosis, Extrinsic Pathway
Entry term(s)	Apoptoses, Extrinsic Pathway Extrinsic Pathway Apoptoses Extrinsic Pathway Apoptosis

Programmed Cell Death - Narrower

Concept UI	M000644348
Scope note	Physiological forms of regulated cell death that occur during growth and development and tissue turnover.
Preferred term	Programmed Cell Death
Entry term(s)	Cell Death, Programmed

Caspase-Dependent Apoptosis - Narrower

Concept UI	M000675620
Preferred term	Caspase-Dependent Apoptosis
Entry term(s)	Apoptosis, Caspase-Dependent Caspase Dependent Apoptosis