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Descriptor English: Apoptosis
Descriptor Spanish: Apoptosis
Descriptor apoptosis
Entry term(s) apoptosis clásica
apoptosis dependiente de caspasas
muerte celular programada
muerte celular programada de tipo I
vía extrínseca de la apoptosis
vía intrínseca de la apoptosis
Scope note: Mecanismo de muerte celular regulada que se caracteriza por cambios morfológicos característicos en el núcleo y en el citoplasma, como la división endonucleótica del ADN genómico, en puntos internucleosómicos regularmente espaciados, es decir, FRAGMENTACIÓN DEL ADN. Está programado genéticamente y sirve como equilibrio para la mitosis en la regulación del tamaño de los tejidos animales y en la mediación de procesos patológicos asociados al crecimiento tumoral.
Descriptor Portuguese: Apoptose
Descriptor French: Apoptose
Entry term(s): Apoptoses, Extrinsic Pathway
Apoptoses, Intrinsic Pathway
Apoptosis, Caspase-Dependent
Apoptosis, Classic
Apoptosis, Classical
Apoptosis, Extrinsic Pathway
Apoptosis, Intrinsic Pathway
Caspase Dependent Apoptosis
Caspase-Dependent Apoptosis
Cell Death, Programmed
Classic Apoptoses
Classic Apoptosis
Classical Apoptosis
Extrinsic Pathway Apoptoses
Extrinsic Pathway Apoptosis
Intrinsic Pathway Apoptoses
Intrinsic Pathway Apoptosis
Programmed Cell Death
Programmed Cell Death, Type I
Tree number(s): G04.146.954.035
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017209
Scope note: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Annotation: general or unspecified, note specifics
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Cell Survival (1972-1992)
Public MeSH Note: 93
History Note: 93
Related: CARD Signaling Adaptor Proteins MeSH
Caspases MeSH
Cellular Apoptosis Susceptibility Protein MeSH
Death Domain Receptor Signaling Adaptor Proteins MeSH
Genes, Transgenic, Suicide MeSH
In Situ Nick-End Labeling MeSH
Necrosis MeSH
DeCS ID: 30827
Unique ID: D017209
NLM Classification: QU 375
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2020/06/09
Apoptosis - Preferred
Concept UI M0026116
Scope note A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Preferred term Apoptosis
Entry term(s) Apoptosis, Classic
Apoptosis, Classical
Classic Apoptoses
Classic Apoptosis
Classical Apoptosis
Programmed Cell Death, Type I
Apoptosis, Intrinsic Pathway - Narrower
Concept UI M0493497
Scope note A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Preferred term Apoptosis, Intrinsic Pathway
Entry term(s) Apoptoses, Intrinsic Pathway
Intrinsic Pathway Apoptoses
Intrinsic Pathway Apoptosis
Apoptosis, Extrinsic Pathway - Narrower
Concept UI M0493496
Scope note A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Preferred term Apoptosis, Extrinsic Pathway
Entry term(s) Apoptoses, Extrinsic Pathway
Extrinsic Pathway Apoptoses
Extrinsic Pathway Apoptosis
Programmed Cell Death - Narrower
Concept UI M000644348
Scope note A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Preferred term Programmed Cell Death
Entry term(s) Cell Death, Programmed
Caspase-Dependent Apoptosis - Narrower
Concept UI M000675620
Preferred term Caspase-Dependent Apoptosis
Entry term(s) Apoptosis, Caspase-Dependent
Caspase Dependent Apoptosis



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