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Descriptor English: Mice, Knockout
Descriptor Spanish: Ratones Noqueados
Descriptor ratones noqueados
Entry term(s) ratones knockout
Scope note: Cepas de ratones cuyo genoma contiene un gen en el que su función ha sido alterada, o bloqueada. Un método común de producir genes alterados utilizando la tecnología del ADN RECOMBINAdo es alterar la secuencia normal del ADN del gen en estudio para impedir la síntesis del producto normal del gen. Las células clonadas en las que esta alteración se produce con éxito se inyectan en los EMBRIONES de ratones, obteniéndose ratones quiméricos. Estos ratones se aparean para producir una cepa en la que todas las células contienen el gen alterado. Los ratones knockout se utilizan como MODELOS ANIMALES EXPERIMENTALES para diversas enfermedades (MODELOS ANIMALES DE ENFERMEDADES) y para esclarecer las funciones de los genes.
Descriptor Portuguese: Camundongos Knockout
Descriptor French: Souris knockout
Entry term(s): Knock-out Mice
Knockout Mice
Knockout Mouse
Mice, Knock out
Mice, Knock-out
Mouse, Knockout
Tree number(s): B01.050.050.136.500.500
B01.050.150.900.649.313.992.635.505.500.550.455
B01.050.150.900.649.313.992.635.505.500.800.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018345
Scope note: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Annotation: NIM no qualif when exper animal; do not forget also to check MICE
Allowable Qualifiers: AB abnormalities
AH anatomy & histology
BL blood
CF cerebrospinal fluid
CL classification
EM embryology
GD growth & development
GE genetics
IM immunology
IN injuries
ME metabolism
MI microbiology
PH physiology
PS parasitology
PX psychology
SU surgery
UR urine
VI virology
Previous Indexing: Mice (1992-1993)
Public MeSH Note: 94
History Note: 94
Related: Gene Knockout Techniques MeSH
DeCS ID: 31308
Unique ID: D018345
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/07/11
Mice, Knockout - Preferred
Concept UI M0027579
Scope note Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Preferred term Mice, Knockout
Entry term(s) Knock-out Mice
Knockout Mice
Knockout Mouse
Mice, Knock out
Mice, Knock-out
Mouse, Knockout



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