| Descriptor English: | Oncogene Proteins v-erbA | ||||||
| Descriptor Spanish: |
Proteínas Oncogénicas v-erbA
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| Descriptor Portuguese: | Proteínas Oncogênicas v-erbA | ||||||
| Descriptor French: | Protéines oncogènes v-erbA | ||||||
| Entry term(s): |
Oncogene Products v erbA Oncogene Products v-erbA Oncogene Proteins v erbA erbA Oncogene Proteins v erbA Proteins v-erbA Proteins |
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| Tree number(s): |
D12.776.624.664.520.750.882 D12.776.964.700.750.882 D12.776.964.775.750.882 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018774 | ||||||
| Scope note: | Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Retroviridae Proteins (1987-1989) Retroviridae Proteins, Oncogenic (1990-1994) |
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| Public MeSH Note: | 95; ONCOGENE PROTEIN ERBA was indexed under RETROVIRIDAE PROTEINS, ONCOGENIC 1990-94 & RETROVIRIDAE PROTEINS 1987-89 |
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| Online Note: | use ONCOGENE PROTEINS V-ERBA (NM) to search ONCOGENE PROTEIN ERBA 1987-94 |
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| History Note: | 95; was ONCOGENE PROTEIN ERBA (NM) 1987-94 |
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| DeCS ID: | 32106 | ||||||
| Unique ID: | D018774 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1995/01/01 | ||||||
| Date of Entry: | 1994/05/23 | ||||||
| Revision Date: | 2018/07/01 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Oncogene Proteins v-erbA
- Preferred
| Concept UI |
M0028105 |
| Scope note | Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation. |
| Preferred term | Oncogene Proteins v-erbA |
| Entry term(s) |
Oncogene Products v erbA Oncogene Products v-erbA Oncogene Proteins v erbA erbA Oncogene Proteins v erbA Proteins v-erbA Proteins |
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