DeCS

Descriptor English:

Oncogene Protein gp140(v-fms)

Descriptor Spanish:

Proteína Oncogénica gp140(v-fms)

Spanish from Spain

Descriptor	proteína oncogénica gp140(v-fms)
Entry term(s)	gp120(v-fms) gp140(v-fms) proteína de oncogén gp120 fms proteína de oncogén gp140 fms proteína de oncogén gp140(v-fms) proteína oncogénica gp120 fms proteína oncogénica gp140 fms proteína v-fms
Scope note:	Glicoproteína transformadora codificada por el oncogen fms a partir de la línea Susan McDonough del virus del sarcoma felino (SM-FeSV). La proteína del oncogen v-fms carece de secuencia, que en la proteína c-fms del proto-oncogen es altamente homóloga (CSF-1 receptor), sirve normalmente para regular su actividad tirosina cinasa. Las secuencias que faltan en el v-fms recuerdan el efecto del ligando y llevan al crecimiento celular constitutivo. La proteína gp120(v-fms) se modifica post-translacionalmente para generar la gp140(v-fms).

Descriptor Portuguese:

Proteína Oncogênica gp140(v-fms)

Descriptor French:

Protéine oncogène gp140(v-fms)

Entry term(s):

fms Oncogene Product gp120
fms Oncogene Product gp140
fms Oncogene Protein gp120
fms Oncogene Protein gp140
gp120 v fms
gp120 v-fms
gp120(v-fms)
gp140 v fms
gp140 v-fms
gp140(v-fms)
v fms Protein
v-fms Protein
v-fms, gp120
v-fms, gp140

Tree number(s):

D12.776.624.664.520.750.650
D12.776.964.700.750.650
D12.776.964.775.750.650

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016281

Scope note:

Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

Annotation:

IM; coord with specific virus (IM); /drug eff /ultrastruct permitted

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M0024883
Scope note	Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
Preferred term	Oncogene Protein gp140(v-fms)
Entry term(s)	fms Oncogene Product gp140 fms Oncogene Protein gp140 gp140 v fms gp140 v-fms gp140(v-fms) v fms Protein v-fms Protein v-fms, gp140

Concept UI	M0024881
Preferred term	fms Oncogene Protein gp120

Concept UI	M0024882
Preferred term	gp120(v-fms)
Entry term(s)	gp120 v fms gp120 v-fms v-fms, gp120

Concept UI	M0024880
Preferred term	fms Oncogene Product gp120

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