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Descriptor English: Interleukin-12
Descriptor Spanish: Interleucina-12
Descriptor interleucina-12
Entry term(s) IL-12
edodecina alfa
factor estimulante de las células citolíticas naturales
interleucina 12
interleucina 12 p70
interleucina-12 p70
Scope note: Citocina heterodimérica que desempeña un papel en las respuestas inmunitarias innatas y adaptativas. La interleucina 12 es una proteína de 70 kDa compuesta de subunidades de 40 t 35 kDa unidas covalentemente. Está producida por las CÉLULAS DENDRÍTICAS, MACRÓFAGOS y una variedad de otras células inmunitarias y desempeña un papel en la estimulación de la producción de INTERFERÓN GAMMA por los LINFOCITOS T y las CÉLULAS CITOLÍTICAS NATURALES.
Descriptor Portuguese: Interleucina-12
Descriptor French: Interleukine-12
Entry term(s): Cytotoxic Lymphocyte Maturation Factor
Edodekin Alfa
IL 12
IL-12
IL-12 p70
IL12
Interleukin 12
Interleukin 12 p70
Interleukin-12 p70
Natural Killer Cell Stimulatory Factor
Tree number(s): D12.644.276.374.465.512
D12.776.467.374.465.512
D23.529.374.465.512
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018664
Scope note: A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adjuvants, Immunologic
Angiogenesis Inhibitors
Registry Number: 187348-17-0
Previous Indexing: Interleukins (1991-1994)
Public MeSH Note: 1995; INTERLEUKIN 12 was indexed under INTERLEUKINS 1991-1994; INTERLEUKIN-12 P70 was indexed under INTERLEUKIN-12 2003-2006
History Note: 1995 (1991)
Related: Immunity, Cellular MeSH
Ustekinumab MeSH
DeCS ID: 32173
Unique ID: D018664
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/04/19
Revision Date: 2018/10/10
Interleukin-12 - Preferred
Concept UI M0027969
Scope note A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Preferred term Interleukin-12
Entry term(s) Cytotoxic Lymphocyte Maturation Factor
IL 12
IL-12
IL-12 p70
IL12
Interleukin 12
Interleukin 12 p70
Interleukin-12 p70
Natural Killer Cell Stimulatory Factor
Edodekin Alfa - Related but not broader or narrower
Concept UI M000642660
Preferred term Edodekin Alfa



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