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Descriptor English: Cyclin-Dependent Kinase Inhibitor p16
Descriptor Spanish: Inhibidor p16 de la Quinasa Dependiente de Ciclina
Descriptor inhibidor p16 de cinasas dependientes de ciclinas
Scope note: Producto del gen p16 supresor de tumores (GENES, P16). Recibe también la denominación de INK4 o de INK4A porque es el miembro prototípico de los INHIBIDORES DE CINASAS DEPENDIENTES DE LA CICLINA INK4. Esta proteína se produce a partir del transcrito ARNm alfa del gen p16. El otro producto génico, producido del transcrito beta ayustado alternativamente, es la PROTEÍNA P14ARF SUPRESORA DE TUMORES. Ambos productos génicos tienen funciones supresoras de tumores.
Descriptor Portuguese: Inibidor p16 de Quinase Dependente de Ciclina
Descriptor French: Inhibiteur p16 de kinase cycline-dépendante
Entry term(s): CDKN2 Protein
CDKN2A Protein
Cdk4 Associated Protein p16
Cdk4-Associated Protein p16
Cyclin Dependent Kinase Inhibitor 2A
Cyclin Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor-2A
INK4A Protein
MTS1 Protein
Multiple Tumor Suppressor 1
Multiple Tumor Suppressor-1
Protein, INK4A
p16(INK4A)
p16INK4 Protein
p16INK4A Protein
Tree number(s): D12.644.360.225.200
D12.776.167.187.200
D12.776.476.225.200
D12.776.624.776.355.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019941
Scope note: A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Carrier Proteins (1994-1997)
Public MeSH Note: 1998; see PROTEIN P16; CDK4-ASSOCIATED PROTEIN P16 was indexed under CARRIER PROTEINS 1994-1997; P16(INK4A) was indexed under CARRIER PROTEINS 2000-2001
History Note: 2006(1994)
Related: Genes, p16 MeSH
Tumor Suppressor Protein p14ARF MeSH
DeCS ID: 33490
Unique ID: D019941
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2015/11/23
Cyclin-Dependent Kinase Inhibitor p16 - Preferred
Concept UI M0029615
Scope note A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Preferred term Cyclin-Dependent Kinase Inhibitor p16
Entry term(s) CDKN2 Protein
CDKN2A Protein
Cdk4 Associated Protein p16
Cdk4-Associated Protein p16
Cyclin Dependent Kinase Inhibitor 2A
Cyclin Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor-2A
INK4A Protein
MTS1 Protein
Multiple Tumor Suppressor 1
Multiple Tumor Suppressor-1
Protein, INK4A
p16(INK4A)
p16INK4 Protein
p16INK4A Protein



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