| Descriptor English: | Receptor, trkA | ||||||
| Descriptor Spanish: |
Receptor trkA
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| Descriptor Portuguese: | Receptor trkA | ||||||
| Descriptor French: | Récepteur trkA | ||||||
| Entry term(s): |
NTRK1 Receptor Neurotrophic Tyrosine Kinase Receptor Type 1 Proto Oncogene Products c trk Proto Oncogene Protein trk Proto-Oncogene Products c-trk Proto-Oncogene Protein trk Proto-Oncogene Protein, trk Receptor, NTRK1 Receptor, Neurotrophic Tyrosine Kinase Type 1 c trk Protein c-trk Protein c-trk, Proto-Oncogene Products c-trk, gp140 gp140 c trk gp140 c-trk gp140(c-TRK) p140 trkA p140-trkA trk Proto Oncogene Protein trk Proto-Oncogene Protein trk, Proto-Oncogene Protein trk1 Transforming Tryrosine Kinase trkA Receptor |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.660 D12.776.476.568.400.660 D12.776.543.750.630.496 D12.776.543.750.750.400.550.550 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D020917 | ||||||
| Scope note: | A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Proto-Oncogene Proteins (1990-1999) Receptor Protein-Tyrosine Kinases (1994-1999) Receptors, Nerve Growth Factor (1994-1999) |
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| Public MeSH Note: | 2000; PROTO-ONCOGENE PROTEIN TRK (now RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE) was indexed under PROTO-ONCOGENE PROTEINS 1990-1999, RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999 & RECEPTORS, NERVE GROWTH FACTOR 1994-1999 |
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| History Note: | 2000; use RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE(NM) 1990-1999 |
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| Entry Version: | RECEPT TRKA |
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| DeCS ID: | 34455 | ||||||
| Unique ID: | D020917 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2000/01/01 | ||||||
| Date of Entry: | 1999/11/04 | ||||||
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Receptor, trkA
- Preferred
| Concept UI |
M0328268 |
| Scope note | A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis. |
| Preferred term | Receptor, trkA |
| Entry term(s) |
NTRK1 Receptor Neurotrophic Tyrosine Kinase Receptor Type 1 Proto Oncogene Products c trk Proto Oncogene Protein trk Proto-Oncogene Products c-trk Proto-Oncogene Protein trk Proto-Oncogene Protein, trk Receptor, NTRK1 Receptor, Neurotrophic Tyrosine Kinase Type 1 c trk Protein c-trk Protein c-trk, Proto-Oncogene Products c-trk, gp140 gp140 c trk gp140 c-trk gp140(c-TRK) p140 trkA p140-trkA trk Proto Oncogene Protein trk Proto-Oncogene Protein trk, Proto-Oncogene Protein trk1 Transforming Tryrosine Kinase trkA Receptor |
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