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Descriptor English: Complementarity Determining Regions
Descriptor Spanish: Regiones Determinantes de Complementariedad
Descriptor regiones determinantes de complementariedad
Scope note: Tres regiones (CDR1, CDR2 y CDR3) de secuencia de aminoácidos en la REGIÓN VARIABLE DE LAS INMUNOGLOBULINAS que son muy divergentes. En conjunto, las CDRs de las cadenas ligeras y pesadas de las inmunoglobulinas forman una superficie que es complementaria al antígeno. Estas regiones se hallan también presentes en otros miembros de la superfamilia de las inmunoglobulinas, por ejemplo, receptores de las células T (RECEPTORES DE ANTÍGENOS DE CÉLULAS T).
Descriptor Portuguese: Regiões Determinantes de Complementaridade
Descriptor French: Régions déterminant la complémentarité
Entry term(s): Complementarity Determining Region
Complementarity Determining Region 1
Complementarity Determining Region 2
Complementarity Determining Region 3
Complementarity Determining Region I
Complementarity Determining Region II
Complementarity Determining Region III
Complementarity-Determining Region
Complementarity-Determining Region 3
Complementarity-Determining Region 3s
Complementarity-Determining Region, Third
Complementarity-Determining Regions
Complementarity-Determining Regions, Third
Hypervariable Region, Immunoglobulin
Hypervariable Regions, Immunoglobulin
Immunoglobulin Hypervariable Region
Immunoglobulin Hypervariable Regions
Region, Complementarity Determining
Region, Immunoglobulin Hypervariable
Regions, Complementarity Determining
Regions, Complementarity-Determining
Regions, Immunoglobulin Hypervariable
Third Complementarity Determining Region
Third Complementarity-Determining Region
Third Complementarity-Determining Regions
Tree number(s): D12.644.541.500.650.500.180
D12.776.124.486.485.680.650.500.180
D12.776.124.486.485.797.180
D12.776.124.790.651.680.650.500.180
D12.776.124.790.651.797.180
D12.776.377.715.548.680.650.500.180
D12.776.377.715.548.797.180
D12.776.543.750.705.816.824.300
G02.111.570.060.425.160
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D022801
Scope note: Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Immunoglobulin Variable Region (1982-2000)
Public MeSH Note: 2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION see IMMUNOGLOBULIN VARIABLE REGION 1988-2000; COMPLEMENTARITY-DETERMINING REGION 3 was indexed under COMPLEMENTARITY DETERMINING REGIONS 1998-2005
History Note: 2001; for COMPLEMENTARITY DETERMINING REGION and HYPERVARIABLE REGION use IMMUNOGLOBULIN VARIABLE REGION 1988-2000
Related: Receptors, Antigen, T-Cell MeSH
DeCS ID: 35339
Unique ID: D022801
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2001/01/01
Date of Entry: 2000/06/22
Revision Date: 2011/06/24
Complementarity Determining Regions - Preferred
Concept UI M0359304
Scope note Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Preferred term Complementarity Determining Regions
Entry term(s) Complementarity Determining Region
Complementarity-Determining Region
Complementarity-Determining Regions
Hypervariable Region, Immunoglobulin
Hypervariable Regions, Immunoglobulin
Immunoglobulin Hypervariable Region
Immunoglobulin Hypervariable Regions
Region, Complementarity Determining
Region, Immunoglobulin Hypervariable
Regions, Complementarity Determining
Regions, Complementarity-Determining
Regions, Immunoglobulin Hypervariable
Complementarity Determining Region 3 - Narrower
Concept UI M0359514
Preferred term Complementarity Determining Region 3
Entry term(s) Complementarity Determining Region III
Complementarity-Determining Region 3
Complementarity-Determining Region 3s
Complementarity-Determining Region, Third
Complementarity-Determining Regions, Third
Third Complementarity Determining Region
Third Complementarity-Determining Region
Third Complementarity-Determining Regions
Complementarity Determining Region 1 - Narrower
Concept UI M0359512
Preferred term Complementarity Determining Region 1
Entry term(s) Complementarity Determining Region I
Complementarity Determining Region 2 - Narrower
Concept UI M0359513
Preferred term Complementarity Determining Region 2
Entry term(s) Complementarity Determining Region II



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