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Descriptor English: Immunoglobulin Joining Region
Descriptor Spanish: Región de Unión de la Inmunoglobulina
Descriptor región de unión de las inmunoglobulinas
Entry term(s) región de unión de Ig
Scope note: Segmento de las cadenas pesadas de las inmunoglobulinas, codificado por los GENES DE LAS CADENAS PESADAS DE LAS INMUNOGLOBULINAS en el segmento J en el que durante la maduración de los LINFOCITOS B el segmento génico para la región variable en sentido proximal se halla unido a un segmento génico de la región constante en sentido distal. La posición exacta de la unión de los dos segmentos génicos es variable y contribuye a la DIVERSIDAD DE ANTICUERPOS. Se diferencia de la CADENA J de las INMUNOGLOBULINAS, polipéptido distinto que sirve como pieza de engarce en la IgA o IgM poliméricas.
Descriptor Portuguese: Região de Junção de Imunoglobulinas
Descriptor French: Région J d'immunoglobuline
Entry term(s): Ig Joining Region
Immunoglobulin Joining Region Peptide Fragments
Joining Region, Ig
Joining Region, Immunoglobulin
Tree number(s): D12.644.541.500.650.500.590
D12.776.124.486.485.680.650.500.590
D12.776.124.486.485.797.590
D12.776.124.790.651.680.650.500.590
D12.776.124.790.651.797.590
D12.776.377.715.548.680.650.500.590
D12.776.377.715.548.797.590
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007133
Scope note: A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Amino Acid Sequence (1971-1987)
Immunoglobulin Constant Region (1979-1987)
Immunoglobulin Variable Region (1977-1987)
Immunoglobulins, Heavy Chain (1977-1987)
Public MeSH Note: 88
History Note: 88
Related: Genes, Immunoglobulin MeSH
DeCS ID: 22919
Unique ID: D007133
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1988/01/01
Date of Entry: 1987/05/11
Revision Date: 2010/06/25
Immunoglobulin Joining Region - Preferred
Concept UI M0011112
Scope note A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
Preferred term Immunoglobulin Joining Region
Entry term(s) Ig Joining Region
Joining Region, Ig
Joining Region, Immunoglobulin
Immunoglobulin Joining Region Peptide Fragments - Related but not broader or narrower
Concept UI M0481959
Preferred term Immunoglobulin Joining Region Peptide Fragments



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