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Descriptor English: Single-Chain Antibodies
Descriptor Spanish: Anticuerpos de Cadena Única
Descriptor anticuerpos de cadena única
Scope note: Anticuerpos que constan solo de las regiones variables de las cadenas ligeras y pesadas (FRAGMENTOS FV) conectadas por un pequeño péptido de unión. Son menos inmunogénicos que la inmunoglobulina completa y, por ello, tienen aplicación terapéutica.
Descriptor Portuguese: Anticorpos de Cadeia Única
Descriptor French: Anticorps à chaîne unique
Entry term(s): Antibodies, ScFv
Antibodies, Single-Chain
Antibody, Single-Chain Fv
Fragment, Single-Chain Variable
Fragments, Single-Chain Variable
Fv Antibody Fragments, Single Chain
Fv Antibody Fragments, Single-Chain
Fv Antibody, Single-Chain
Fv, Single-Chain
ScFv Antibodies
Single Chain Antibodies
Single Chain Fv
Single Chain Fv Antibody
Single Chain Fv Antibody Fragments
Single Chain Variable Fragment
Single Chain Variable Fragment Antibodies
Single Chain Variable Fragment Antibody
Single Chain Variable Fragments
Single-Chain Fv
Single-Chain Fv Antibody
Single-Chain Fv Antibody Fragments
Single-Chain Variable Fragment
Single-Chain Variable Fragment Antibodies
Single-Chain Variable Fragment Antibody
Single-Chain Variable Fragments
Variable Fragment, Single-Chain
Variable Fragments, Single-Chain
Tree number(s): D12.644.541.500.650.500.800
D12.776.124.486.485.114.224.785
D12.776.124.486.485.680.650.500.800
D12.776.124.790.651.680.650.500.800
D12.776.377.715.548.680.650.500.795
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D057127
Scope note: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antibodies or specifics (1990-2009)
Immunoglobulin Fragments (1992-2009)
Immunoglobulin Variable Region (1993-2009)
Public MeSH Note: 2010
History Note: 2010
Related: Single-Domain Antibodies MeSH
DeCS ID: 53639
Unique ID: D057127
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2012/07/03
Single-Chain Antibodies - Preferred
Concept UI M0534715
Scope note A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Preferred term Single-Chain Antibodies
Entry term(s) Antibodies, ScFv
Antibodies, Single-Chain
Antibody, Single-Chain Fv
Fragment, Single-Chain Variable
Fragments, Single-Chain Variable
Fv Antibody Fragments, Single Chain
Fv Antibody Fragments, Single-Chain
Fv Antibody, Single-Chain
Fv, Single-Chain
ScFv Antibodies
Single Chain Antibodies
Single Chain Fv
Single Chain Fv Antibody
Single Chain Fv Antibody Fragments
Single Chain Variable Fragment
Single Chain Variable Fragment Antibodies
Single Chain Variable Fragment Antibody
Single Chain Variable Fragments
Single-Chain Fv
Single-Chain Fv Antibody
Single-Chain Fv Antibody Fragments
Single-Chain Variable Fragment
Single-Chain Variable Fragment Antibodies
Single-Chain Variable Fragment Antibody
Single-Chain Variable Fragments
Variable Fragment, Single-Chain
Variable Fragments, Single-Chain



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