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Descriptor in English: Dactinomycin
Descriptor in Spanish: Dactinomicina
Descriptor in Portuguese: Dactinomicina
Descriptor in French: Dactinomycine
Entry term(s): Actinomycin
Actinomycin D
Cosmegen
Cosmegen Lyovac
Lyovac Cosmegen
Lyovac, Cosmegen
Lyovac-Cosmegen
LyovacCosmegen
Meractinomycin
Tree number(s): D03.633.300.200
D04.345.566.252
D12.644.641.252
Scope note: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 66; ACTINOMYCIN was heading 1963-95
DeCS UI: 3628
Descriptor UI: D003609
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Dactinomycin - Preferred
Concept UI M0005644
Scope note A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Preferred term Dactinomycin
Entry term(s) Actinomycin D
Meractinomycin
Actinomycin - Broader
Concept UI M0005643
Preferred term Actinomycin
Cosmegen - Narrower
Concept UI M0354002
Preferred term Cosmegen
Entry term(s) Cosmegen Lyovac
Lyovac Cosmegen
Lyovac, Cosmegen
Lyovac-Cosmegen
LyovacCosmegen



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