Descriptor English: | Simeprevir |
Descriptor Spanish: | Simeprevir |
Descriptor Portuguese: | Simeprevir |
Descriptor French: | Siméprévir |
Entry term(s): |
435, TMC 435350, TMC N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide Olysio TMC 435 TMC 435350 TMC-435 TMC-435350 TMC435 TMC435350 |
Tree number(s): |
D02.886.590.700.700 D03.633.300.819 |
RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000069616 |
Scope note: | Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. |
Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
Pharm Action: |
Antiviral Agents Protease Inhibitors |
Registry Number: | 9WS5RD66HZ |
Public MeSH Note: | 2016; SIMEPREVIR was indexed under SULFONAMIDES and HETEROCYCLIC COMPOUNDS, 3-RING 2008-2015 |
History Note: | 2016 (2008) |
DeCS ID: | 55903 |
Unique ID: | D000069616 |
Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents |
Date Established: | 2016/01/01 |
Date of Entry: | 2015/07/10 |
Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
|
Simeprevir
- Preferred
TMC 435350
- Narrower
TMC 435
- Narrower
Olysio
- Narrower
Concept UI |
M0526124 |
Scope note | Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. |
Preferred term | Simeprevir |
Entry term(s) |
N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide |
Concept UI |
M0526125 |
Preferred term | TMC 435350 |
Entry term(s) |
435350, TMC TMC-435350 TMC435350 |
Concept UI |
M0542310 |
Preferred term | TMC 435 |
Entry term(s) |
435, TMC TMC-435 TMC435 |
Concept UI |
M0589260 |
Preferred term | Olysio |
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