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Descriptor English: Simeprevir
Descriptor Spanish: Simeprevir
Descriptor simeprevir
Scope note: INHIBIDOR DE PROTEASA del VHC que se administra por vía oral, eficaz contra la serina proteasa NS3/4A del virus de la hepatitis C. Se utiliza en el tratamiento de la infección por el genotipo 1 de la hepatitis crónica C (Antivirales) en adultos con enfermedad hepática compensada, incluyendo la CIRROSIS.
Descriptor Portuguese: Simeprevir
Descriptor French: Siméprévir
Entry term(s): 435, TMC
435350, TMC
N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide
Olysio
TMC 435
TMC 435350
TMC-435
TMC-435350
TMC435
TMC435350
Tree number(s): D02.886.590.700.700
D03.633.300.819
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000069616
Scope note: Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiviral Agents
Protease Inhibitors
Registry Number: 9WS5RD66HZ
Public MeSH Note: 2016; SIMEPREVIR was indexed under SULFONAMIDES and HETEROCYCLIC COMPOUNDS, 3-RING 2008-2015
History Note: 2016 (2008)
DeCS ID: 55903
Unique ID: D000069616
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2016/01/01
Date of Entry: 2015/07/10
Revision Date: 2016/05/31
Simeprevir - Preferred
Concept UI M0526124
Scope note Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS.
Preferred term Simeprevir
Entry term(s) N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide
TMC 435350 - Narrower
Concept UI M0526125
Preferred term TMC 435350
Entry term(s) 435350, TMC
TMC-435350
TMC435350
TMC 435 - Narrower
Concept UI M0542310
Preferred term TMC 435
Entry term(s) 435, TMC
TMC-435
TMC435
Olysio - Narrower
Concept UI M0589260
Preferred term Olysio



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