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Descriptor English: Genes, BRCA2
Descriptor Spanish: Genes BRCA2
Descriptor genes BRCA2
Entry term(s) gen BRCA2
Scope note: Gen supresor de tumor (GENES SUPRESORES DE TUMOR) localizado en el cromosoma 13 humano en el locus 13q12.3. Las mutaciones de este gen predisponen al cáncer de mama y ovario. Este gen codifica una proteína nuclear grande que es un componente de las vías de reparación del ADN e inhibe importantes reordenamientos cromosómicos. (Traducción libre del original: Genes Dev 2000;14(11):1400-6).
Descriptor Portuguese: Genes BRCA2
Descriptor French: Gène BRCA2
Entry term(s): BRCA2 Gene
BRCA2 Genes
Gene, BRCA2
Tree number(s): G05.360.340.024.340.375.249.105
G05.360.340.024.340.415.400.105
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D024522
Scope note: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
Annotation: BRCA stands for "BReast CAncer"
Allowable Qualifiers: DE drug effects
ES ethics
PH physiology
RE radiation effects
Previous Indexing: Genes, Tumor Suppressor (1995-2001)
Public MeSH Note: 2002
History Note: 2002
Related: BRCA2 Protein MeSH
DeCS ID: 36331
Unique ID: D024522
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2008/07/08
Genes, BRCA2 - Preferred
Concept UI M0370672
Scope note A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
Preferred term Genes, BRCA2
Entry term(s) BRCA2 Gene
BRCA2 Genes
Gene, BRCA2



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