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Descriptor English: Genes, BRCA1
Descriptor Spanish: Genes BRCA1
Descriptor genes BRCA1
Entry term(s) gen BRCA1
Scope note: Gen supresor de tumores (GENES SUPRESORES DE TUMORES) localizado en el cromosoma 17 humano, locus 17q21. Las mutaciones de este gen se asocian con la formación del SÍNDROME DE CÁNCER HEREDITARIO DE MAMA Y OVARIO. Este gen codifica una proteína nuclear de gran tamaño que es un componente de las vías de reparación del ADN.
Descriptor Portuguese: Genes BRCA1
Descriptor French: Gène BRCA1
Entry term(s): BRCA1 Gene
BRCA1 Genes
Gene, BRCA1
Tree number(s): G05.360.340.024.340.375.249.100
G05.360.340.024.340.415.400.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019398
Scope note: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.
Annotation: BRCA stands for "BReast CAncer"
Allowable Qualifiers: DE drug effects
PH physiology
RE radiation effects
Previous Indexing: Genes, Suppressor, Tumor (1993-1996)
Public MeSH Note: 97
History Note: 97
Related: BRCA1 Protein MeSH
DeCS ID: 33161
Unique ID: D019398
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2014/06/06
Genes, BRCA1 - Preferred
Concept UI M0028862
Scope note A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.
Preferred term Genes, BRCA1
Entry term(s) BRCA1 Gene
BRCA1 Genes
Gene, BRCA1



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