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Descriptor English: Genes, Retinoblastoma
Descriptor Spanish: Genes de Retinoblastoma
Descriptor genes del retinoblastoma
Entry term(s) genes Rb
Scope note: Genes supresores de tumor localizados en la región13q14 del cromosoma 13, que codifican una familia de fosfoproteínas cuyos pesos moleculares oscilan entre 104 kDa y 115 kDa. Para el desarrollo retiniano normal es necesaria una copia del gen Rb salvaje. La pérdida o inactivación de ambos alelos de este locus se sigue de retinoblastoma.
Descriptor Portuguese: Genes do Retinoblastoma
Descriptor French: Gènes du rétinoblastome
Entry term(s): Gene, Rb
Gene, Retinoblastoma
Genes, Rb
Rb Gene
Rb Genes
Retinoblastoma Gene
Retinoblastoma Genes
Tree number(s): G05.360.340.024.340.375.249.400
G05.360.340.024.340.415.400.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016161
Scope note: Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Retinoblastoma/genetics (1972-1990)
Public MeSH Note: 91
History Note: 91
Related: Retinoblastoma MeSH
DeCS ID: 28960
Unique ID: D016161
NLM Classification: QZ 210
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/05/07
Revision Date: 2010/06/25
Genes, Retinoblastoma - Preferred
Concept UI M0024674
Scope note Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
Preferred term Genes, Retinoblastoma
Entry term(s) Gene, Rb
Gene, Retinoblastoma
Genes, Rb
Rb Gene
Rb Genes
Retinoblastoma Gene
Retinoblastoma Genes



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