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Descriptor English: Single-Strand Specific DNA and RNA Endonucleases
Descriptor Spanish: Endonucleasas Específicas del ADN y ARN con un Solo Filamento
Descriptor endonucleasas específicas de ADN y ARN monocatenarios
Scope note: Enzimas que catalizan la segmentación endonucleolítica de las regiones monocatenarias de las moléculas de ADN o ARN, dejando las regiones bicatenarias intactas. Son particularmente útiles en el laboratorio para producir moléculas de ADN "de extremos romos" a partir de ADN con terminaciones monocatenarias y para TÉCNICAS GENÉTICAS, tales como ENSAYOS DE PROTECCIÓN DE NUCLEASAS que involucran la detección de ADN y ARN monocatenarios.
Descriptor Portuguese: Endonucleases Específicas para DNA e RNA de Cadeia Simples
Descriptor French: Single-Strand Specific DNA and RNA Endonucleases
Entry term(s): Single Strand Specific DNA and RNA Endonucleases
Tree number(s): D08.811.277.352.335.350.700
D08.811.277.352.355.325.700
D08.811.277.352.355.350.820
D08.811.277.352.700.350.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015719
Scope note: Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecules while leaving the double-stranded regions intact. They are particularly useful in the laboratory for producing "blunt-ended" DNA molecules from DNA with single-stranded ends and for sensitive GENETIC TECHNIQUES such as NUCLEASE PROTECTION ASSAYS that involve the detection of single-stranded DNA and RNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.30.1
Previous Indexing: Endonucleases (1973-1989)
Phosphodiesterases (1972)
Public MeSH Note: 2008; see ASPERGILLUS NUCLEASE S1 1990-2008
History Note: 2009(1990)
DeCS ID: 24528
Unique ID: D015719
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2010/06/25
Single-Strand Specific DNA and RNA Endonucleases - Preferred
Concept UI M0517901
Scope note Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecules while leaving the double-stranded regions intact. They are particularly useful in the laboratory for producing "blunt-ended" DNA molecules from DNA with single-stranded ends and for sensitive GENETIC TECHNIQUES such as NUCLEASE PROTECTION ASSAYS that involve the detection of single-stranded DNA and RNA.
Preferred term Single-Strand Specific DNA and RNA Endonucleases
Entry term(s) Single Strand Specific DNA and RNA Endonucleases



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