| Descriptor English: | Iron Regulatory Protein 1 | ||||||
| Descriptor Spanish: |
Proteína 1 Reguladora de Hierro
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| Descriptor Portuguese: | Proteína 1 Reguladora do Ferro | ||||||
| Descriptor French: | Protéine-1 de régulation du fer | ||||||
| Entry term(s): |
ACO1 Protein Aconitase 1, Soluble Ferritin Repressor Protein IRE BP1 IRE-BP1 IRP 1 Protein IRP-1 Protein IRP1 Protein Repressor Protein, Ferritin Soluble Aconitase 1 |
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| Tree number(s): |
D08.811.520.241.300.050.500 D12.776.157.427.374.375.960 D12.776.157.725.374 D12.776.494.500 D12.776.556.579.374.375.960 D12.776.664.962.374 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D035941 | ||||||
| Scope note: | A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 4.2.1.3 | ||||||
| Previous Indexing: |
Iron-Sulfur Proteins (1995-2002) Ribonucleoproteins (1995-2002) |
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| Public MeSH Note: | 2003; FERRITIN REPRESSOR PROTEIN was indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1991-2002, IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN were indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1995-2002 |
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| History Note: | 2003; for FERRITIN REPRESSOR PROTEIN use IRON-REGULATORY PROTEINS (NM) 1991-2002, for IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002 |
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| DeCS ID: | 37326 | ||||||
| Unique ID: | D035941 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/02 | ||||||
| Revision Date: | 2006/07/05 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Iron Regulatory Protein 1
- Preferred
| Concept UI |
M0175229 |
| Scope note | A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON. |
| Preferred term | Iron Regulatory Protein 1 |
| Entry term(s) |
ACO1 Protein Aconitase 1, Soluble Ferritin Repressor Protein IRE BP1 IRE-BP1 IRP 1 Protein IRP-1 Protein IRP1 Protein Repressor Protein, Ferritin Soluble Aconitase 1 |
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