| Descriptor English: | Iron Regulatory Protein 2 | ||||||
| Descriptor Spanish: |
Proteína 2 Reguladora de Hierro
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| Descriptor Portuguese: | Proteína 2 Reguladora do Ferro | ||||||
| Descriptor French: | Protéine-2 de régulation du fer | ||||||
| Entry term(s): |
IRE-BP2 IREB2 Protein IRP 2 RNA binding protein IRP-2 RNA-binding protein IRP2 Protein Iron-Responsive-Element Binding Protein 2 RNA-binding protein, IRP-2 |
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| Tree number(s): |
D08.811.520.241.300.050.750 D12.776.157.427.374.375.961 D12.776.157.725.437 D12.776.494.750 D12.776.556.579.374.375.962 D12.776.664.962.437 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D035942 | ||||||
| Scope note: | A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 4.2.1.3 | ||||||
| Previous Indexing: |
Iron-Sulfur Proteins (1995-2002) Ribonucleoproteins (1995-2002) |
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| Public MeSH Note: | 2003; IRON REGULATORY PROTEIN 2, IRE-BP2 & IRP-2 RNA-BINDING PROTEIN were indexed under RNA-BINDING PROTEINS & IRON-SULFUR PROTEINS 1995-2002 |
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| History Note: | 2003; for IRON REGULATORY PROTEIN 2, IRE-BP2 & IRP-2 RNA-BINDING PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002 |
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| DeCS ID: | 37327 | ||||||
| Unique ID: | D035942 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2006/07/05 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Iron Regulatory Protein 2
- Preferred
| Concept UI |
M0175238 |
| Scope note | A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its rate of degradation is increased in the presence of IRON. |
| Preferred term | Iron Regulatory Protein 2 |
| Entry term(s) |
IRE-BP2 IREB2 Protein IRP 2 RNA binding protein IRP-2 RNA-binding protein IRP2 Protein Iron-Responsive-Element Binding Protein 2 RNA-binding protein, IRP-2 |
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