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Descriptor English: Poly(A)-Binding Protein II
Descriptor Spanish: Proteína II de Unión a Poli(A)
Descriptor proteína II de unión-poli(A)
Scope note: Proteína de unión a poli(A) implicada en la promoción de la extensión de las colas de poli A del ARNM. La proteína requiere un mínimo de diez nucleótidos de ADENOSINA para unirse al ARNm. Una vez unida trabaja junto con un FACTOR DE ESPECIFICIDAD DE LA ESCISIÓN Y POLIADENILACIÓN para estimular la velocidad de síntesis por la POLI A POLIMERASA. Una vez que las colas de poli-A alcanzan aproximadamente 250 nucleótidos de longitud, la proteína II de unión poli(A) ya no estimula la POLIADENILACIÓN. Se ha demostrado que las mutaciones en el interior de una región con una repetición GCG en el gen para la proteína II de unión poli(A) causan la enfermedad de DISTROFIA MUSCULAR OCULOFARÍNGEA.
Descriptor Portuguese: Proteína II de Ligação a Poli(A)
Descriptor French: Protéine-2 de liaison au poly(A)
Entry term(s): PAB II
PAB2 Poly(A) Binding Protein
PABP2
Pabp2 Gene Product
Pabp2 Protein
Poly(A) Binding Protein II
Poly(A) Binding Protein, Nuclear 1
Tree number(s): D12.776.157.725.452.500
D12.776.664.962.452.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039103
Scope note: A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA-Binding Proteins (1995-2002)
Public MeSH Note: 2003; PAB II was indexed under RNA-BINDING PROTEINS 1995-2002; PABP2 GENE PRODUCT & PABP2 PROTEIN were indexed under RNA-BINDING PROTEINS 1999-2002; PABP2 was indexed under RNA-BINDING PROTEINS 2000-2002
History Note: 2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002
Related: Muscular Dystrophy, Oculopharyngeal MeSH
DeCS ID: 37408
Unique ID: D039103
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Poly(A)-Binding Protein II - Preferred
Concept UI M0103425
Scope note A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Preferred term Poly(A)-Binding Protein II
Entry term(s) PAB II
PAB2 Poly(A) Binding Protein
PABP2
Pabp2 Gene Product
Pabp2 Protein
Poly(A) Binding Protein II
Poly(A) Binding Protein, Nuclear 1



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