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Descriptor English: T-Cell Intracellular Antigen-1
Descriptor Spanish: Antígeno Intracelular 1 de las Células T
Descriptor antígeno intracelular 1 de las células T
Entry term(s) proteína de unión a ARN TIA-1
Scope note: Proteína de unión a ARN caracterizada por tres MOTIVOS DE RECONOCIMIENTO DE ARN. Se une a ELEMENTOS RICOS EN ADENILATO Y URIDILATO en las regiones no traducidas 3' del ARNm y regula el corte y empalme alternativo del preARN y la traducción del ARNm; también actúa en la APOPTOSIS. Las mutaciones del gen TIA-1 se asocian a la MIOPATÍA DISTAL DE WELANDER.
Descriptor Portuguese: Antígeno-1 Intracelular de Células T
Descriptor French: Antigène intracellulaire-1 des lymphocytes T
Entry term(s): Intracellular Antigen-1, T-Cell
Intracellular Antigen-1, T-Cell-Restricted
RNA Binding Protein TIA 1
RNA-Binding Protein TIA-1
T Cell Intracellular Antigen 1
T Cell Restricted Intracellular Antigen 1
T-Cell-Restricted Intracellular Antigen-1
TIA-1, RNA-Binding Protein
Tree number(s): D12.776.157.725.452.750
D12.776.157.725.813.937
D12.776.157.725.829.875
D12.776.664.962.452.750
D12.776.664.962.813.937
D12.776.664.962.829.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074019
Scope note: An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA-Binding Proteins (1991-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57100
Unique ID: D000074019
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
T-Cell Intracellular Antigen-1 - Preferred
Concept UI M000625192
Scope note An RNA-binding protein characterized by three RNA RECOGNITION MOTIFS. It binds to AU RICH ELEMENTS in the 3'-untranslated regions of mRNA and regulates alternative pre-RNA splicing and mRNA translation; it may also function in APOPTOSIS. Mutations in the TIA-1 gene are associated with WELANDER DISTAL MYOPATHY.
Preferred term T-Cell Intracellular Antigen-1
Entry term(s) Intracellular Antigen-1, T-Cell
Intracellular Antigen-1, T-Cell-Restricted
RNA Binding Protein TIA 1
RNA-Binding Protein TIA-1
T Cell Intracellular Antigen 1
T Cell Restricted Intracellular Antigen 1
T-Cell-Restricted Intracellular Antigen-1
TIA-1, RNA-Binding Protein



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